Results 101 to 110 of about 5,964,638 (304)

Multiple Mechanisms for the Action of Chymase Inhibitors

Journal of Pharmacological Sciences, 2012
Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj   +1 more source

Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro

, 2014
Aim: To identify a key protein that binds monomeric G protein RhoA and activates the RhoA/Rho kinase/MYPT1 axis in vascular smooth muscle cells (VSMCs) upon angiotensin II (Ang II) stimulation.
Chiu, Wei-chiao;Juang, Jyh-ming;Chang, Shen-nan;Wu, Cho-kai;Tsai, Chia-ti;Tseng, Yung-zu;Chiang, Fu-tien, 曾淵如 ;張勝南 ;江福田 ;吳卓鍇 ;莊志明 ;蔡佳醍   +1 more
core   +1 more source

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source

Mild hypothermia alleviates post-resuscitation cerebral injury in rats via modulating the balance of the renin–angiotensin system

Resuscitation Plus
Cardiac arrest and cardiopulmonary resuscitation represent a major cause of mortality. Cerebral ischemia–reperfusion injury following Cardiac arrest and cardiopulmonary resuscitation leads to severe neurological deficits and significantly worsens patient
Yongjing He, Qianqian Wu, Sisi Huang, Dan Wu, Yuansheng Zhan, Jiaqiang Deng, Beizhu Xu, Lu Xie, Junhui Zheng   +8 more
doaj   +1 more source

Antihypertensive effects of angiotensin-(1-7)

Brazilian Journal of Medical and Biological Research, 1998
Accumulating evidence suggests that angiotensin-(1-7) (Ang-(1-7)) is an important component of the renin-angiotensin system and that the actions of the peptide may either contribute to or oppose those of Ang II.
M.C. Chappell, S.N. Iyer, D.I. Diz, C.M. Ferrario   +3 more
doaj   +1 more source

EARLY DOWN-REGULATIONOF ANGIOTENSIN II RECEPTORS GENE EXPRESSION IN CULTURED HUMAN MESANGIAL CELLS BY ANGIOTENSIN II

, 1999
Internat.
CANTARO S, L. Calò, MEANI A, A. Meani, CALO', LORENZO, S. Cantaro, PRIANTE, GIOVANNA, D'ANGELO, ANGELA, NALESSO F, F. Nalesso   +9 more
core  

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I–Infused Rats

Journal of Pharmacological Sciences, 2013
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor ...
Keisuke Ohnishi, Miki Murase, Daisuke Nakano, Nicolas Pelisch, Hirofumi Hitomi, Hiroyuki Kobori, Satoshi Morimoto, Hirohito Mori, Tsutomu Masaki, Koji Ohmori, Masakazu Kohno, Atsuhiro Ichihara, Akira Nishiyama   +12 more
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and cardiac
Bo Liu, Heng Zeng, Han Su, Quinesha A. Williams, Jessie Besanson, Yingjie Chen, Jian‐Xiong Chen   +6 more
doaj   +1 more source