Results 101 to 110 of about 6,209,552 (299)

Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and cardiac
Bo Liu   +6 more
doaj   +1 more source

Roles and functions of Atp6ap2 in the brain

open access: yesNeural Regeneration Research, 2018
The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke   +1 more
doaj   +1 more source

Effect of renal denervation on Renin-Angiotensin-Aldosterone System (RAAS).

open access: yes, 2016
Plasma levels of rennin (A), angiotensin-II (B) and aldosterone (C) in the sham-operated, abdominal aortic constriction (AAC), abdominal aortic constriction with renal denervation (AAC-RD) groups.
Yong Wei (44544)   +5 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra   +8 more
wiley   +1 more source

The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatment

open access: yes, 2022
SARS-CoV-2 interacting with its receptor, angiotensin-converting enzyme 2 (ACE2), turns the host response to viral infection into a dysregulated uncontrolled inflammatory response. This is because ACE2 limits the production of the peptide angiotensin II (
Richard Head (2217217)   +6 more
core  

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza   +12 more
wiley   +1 more source

ANGIOTENSIN II AND MYOCARDIAL INFARCTION

open access: yesРациональная фармакотерапия в кардиологии, 2016
The role of angiotensin II in pathogenesis of cardiovascular diseases is discussed. Angiotensin II participates in development of acute myocardial infarction (MI) in patients with atherosclerosis.
O. P. Shevchenko, А. О. Shevchenko
doaj   +1 more source

Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia

open access: yes, 2008
Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic ...
McKee, Mary   +5 more
core   +1 more source

Comparative treatment effects of direct oral anticoagulants versus warfarin for nonvalvular atrial fibrillation in clinical practice vary over time due to channelling

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Temporal shifts in patient characteristics can influence comparative treatment effects within a certain indication. We investigated patient characteristics and comparative effectiveness and safety for direct oral anticoagulants (DOACs) and warfarin over the time period where DOACs replaced warfarin as preferred stroke prophylaxis in patients with ...
Raoul B. L. J. van den Hemel   +6 more
wiley   +1 more source

Effect of Angiotensin II on Blood Flow in Acute and Chronically Inflamed Knee Joints of Rabbits: The Role of Nitric Oxide [PDF]

open access: yesIranian Journal of Medical Sciences, 2009
Background: Angiotensin converting enzyme (ACE) upregulationin stromal cells of joints affected by rheumatoid arthritismay lead to higher tissue angiotensin II that is a vasoconstrictorand mitogen factor.
Hamid Najafipour   +3 more
doaj  

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