Results 221 to 230 of about 37,412 (255)

Angiotensin II receptor antagonists

Lancet, The, 2000
Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors.
Michel Burnier, H R Brunner
exaly   +6 more sources

Nonpeptide Angiotensin II Receptor Antagonists

American Journal of Hypertension, 1990
Although the most direct way to interfere with the renin-angiotensin system (RAS) is at the level of the angiotensin II (AII) receptor, the currently available AII receptor antagonists are peptides still retaining significant agonistic properties with the obvious drawbacks of limited stability and lack of oral activity.
Pieter B M W M Timmermans, David J Carini, Andrew T Chiu   +2 more
exaly   +3 more sources

Comparative pharmacology of the angiotensin II receptor antagonists

Expert Opinion on Investigational Drugs, 1998
The non-peptide angiotensin II (AII) receptor antagonists are a new class of compounds that are continuing to be developed as therapeutic agents for the treatment of hypertension, heart failure (HF) and chronic renal disease (CRD). Several of these compounds are currently available for therapeutic use in the USA and the European community with several ...
exaly   +3 more sources

Angiotensin II receptor antagonists and the kidney

Current Opinion in Nephrology and Hypertension, 1994
The kidney is not only the source of circulating renin, which determines the plasma concentration of angiotensin II, but it is also one of the main targets of angiotensin II. Thus, angiotensin II exerts an important physiologic influence on renal function through its ability to modulate renal hemodynamics as well as glomerular and tubular functions ...
Burnier M, Brunner HR
openaire   +3 more sources

Overview of angiotensin II-receptor antagonists

The American Journal of Cardiology, 1998
T renin–angiotensin system is integral to the mechanisms that regulate cardiovascular homeostasis. The renin–angiotensin system has an important role in the pathophysiology of hypertension and heart failure via the vasoconstricting effects of angiotensin II, which sustain elevated blood pressure levels in hypertension and increase afterload in chronic ...
B, Pitt, M A, Konstam
openaire   +2 more sources

Dihydropyrimidine angiotensin II receptor antagonists

Journal of Medicinal Chemistry, 1992
The discovery of the nonpeptide angiotensin II (AII) receptor antagonist losartan, previously called DuP 753, has stimulated considerable interest in the synthesis of novel analogs of this compound. Our efforts in this area have resulted in the discovery of dihydropyrimidines as potent AII receptor antagonists. The chemistry leading to this novel class
K S, Atwal, S Z, Ahmed, J E, Bird, C L, Delaney, K E, Dickinson, F N, Ferrara, A, Hedberg, A V, Miller, S, Moreland, B C, O'Reilly   +9 more
openaire   +2 more sources

Nonpeptide angiotensin II receptor antagonists

Trends in Pharmacological Sciences, 1991
Substantial progress has been made recently in the development of nonpeptide angiotensin II receptor antagonists, a goal that has long remained an unmet challenge. Pieter Timmermans and colleagues review the pharmacology and the course of events that led to the identification of the lead compound and clinical candidate DuP753. Nonpeptide angiotensin II
P B, Timmermans, P C, Wong, A T, Chiu, W F, Herblin   +3 more
openaire   +2 more sources

Angiotensin II receptor antagonists and receptor subtypes

Trends in Endocrinology & Metabolism, 1992
Recently discovered nonpeptide angiotensin II receptor antagonists represent a new class of potential drugs for the treatment of hypertension and congestive heart failure. Further, these antagonists have been successfully used as selective research tools for physiologic studies of angiotensin H and defining angiotensin II receptor subtypes.
P C, Wong, A T, Chiu, J V, Duncia, W F, Herblin, R D, Smith, P B, Timmermans   +5 more
openaire   +2 more sources

Angiotensin II Receptor Antagonists

High Blood Pressure & Cardiovascular Prevention, 2007
Stroke is a devastating disease that heavily affects overall cardiovascular mortality and quality of life in surviving patients, and has a relevant burden on healthcare systems. Recent data derived both from large epidemiological surveys and from the analysis of events occurring in the clinical trials on hypertension, performed over the last 10 years ...
Giuliano Tocci, Francesca Giovannelli, Caterina Facciolo   +2 more
openaire   +1 more source