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Angiotensin II Receptor Blockers in Heart Failure
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003Heart failure remains a significant cause of morbidity and mortality, despite major advances in therapy. Angiotensin II, the principal mediator of the renin‐angiotensin system, exerts both short‐term (e.g., hemodynamic, renal) and long‐term (e.g., inflammation, cardiac remodeling) effects in the pathophysiology of cardiovascular disease. The effects of
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Angiotensin II Receptor Blockers in Older Patients
The American Journal of Geriatric Cardiology, 2004Older patients with hypertension are often inadequately treated due to misconceptions regarding reasonable goal blood pressures or concerns about treatment side effects. Adequately treating hypertension can yield impressive benefits in terms of improved morbidity and enhanced quality of life in persons of any age. Antagonists of the renin‐
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Angiotensin II Receptor Blockers
2001The angiotensin II (Ang II) receptor antagonists are the most selective blockers of the renin-angiotensin system (RAS) currently available. The efficacy of these drugs is similar to that of the other major antihypertensive drug classes, but they appear to exhibit fewer side effects. Angiotensin receptor blockers (ARBs) selectively block the angiotensin
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Treating Hypertension with Angiotensin II Receptor Blockers
High Blood Pressure & Cardiovascular Prevention, 2005The clinical use of angiotensin II receptor blockers (ARBs) has resulted in the effective and successful treatment of arterial hypertension, and vast experience has been gained by physicians in this original indication over the last years. Furthermore, promising results have been obtained with the use of ARBs in other clinical conditions, such as type ...
Luis M Ruilope, Massimo Volpe
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Angiotensin II-receptor blockers: Clinical relevance and therapeutic role
American Journal of Health-System Pharmacy, 2001The limitations of angiotensin-converting-enzyme (ACE) inhibitors and the role of angiotensin II-receptor blockers (ARBs) in the treatment of hypertension, heart failure, and diabetic nephropathy are discussed. Although ACE inhibitors are generally well tolerated, two important class-related adverse effects are cough, which is common, and angioedema ...
J E, Rodgers, J H, Patterson
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Effects of angiotensin II receptor blockers on diabetic nephropathy
Journal of Hypertension, 2009Impaired kidney function increases the risk of cardiovascular morbidity and mortality. Coexistence of hypertension and type 2 diabetes increases the risk of kidney damage, hypertension being an independent risk factor for kidney disease progression. Angiotensin II, through its inflammatory, proliferative, and thrombotic effects, adversely affects renal
Rigas, Kalaitzidis, George L, Bakris
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Vascular and metabolic effects of angiotensin II receptor blockers
Expert Opinion on Pharmacotherapy, 2009Angiotensin II receptor blockers (ARBs) are widely used in patients with hypertension, heart failure and type 2 diabetes mellitus (T2DM). Several large clinical trials have demonstrated that these agents are effective in reducing cardiovascular mortality and morbidity.
Silvia, Barra +4 more
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Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
2014Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) play a pivotal role in the management of heart failure (HF) and hypertension. These agents are mildly cardioprotective and increase survival somewhat in patients with:
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Angiotensin II receptor blockers
Coronary Artery Disease, 1999H, Thai, T, Raya
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Frictional purpuric eruption associated with angiotensin II receptor blockers.
Dermatologic therapy, 2014Angiotensin II receptor blockers (ARBs) are drugs generally well tolerated. There are few reports about cutaneous side effects of ARBs. The present authors describe herein four cases of purpuric eruption mainly involving sites of friction in patients taking ARBs.
Foti, C. +7 more
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