Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of ACE2/AT2R/Mas [PDF]
, 2016 High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze +10 more
core +1 more source
Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease
Clinical and Experimental Hypertension, 2018 Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj +1 more source
Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction [PDF]
, 1994 Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction. We have shown that acute (24-hr) unilateral ureteral obstruction (UUO) induces the genes encoding for renin, in juxtaglomerular apparatuses and in tubules, for
Pimentel, J. Luis +2 more
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Bortezomib-containing multimodality treatment for antibody-mediated rejection with anti-HLA and anti-AT1R antibodies after kidney transplantation [PDF]
, 2017 For decades, the human leukocyte antigen (HLA) complex has been considered the primary target of antibody-mediated rejection (AMR), and treatment strategies have mainly focused on anti-HLA antibodies.
Favi, Evaldo +3 more
core +1 more source
Preeclampsia, the Renin-Angiotensin-Aldosterone System and beyond [PDF]
, 2015 __Abstract__ The renin-angiotensin-aldosterone system (RAAS) plays an essential role in the regulation of blood pressure and body fluid homeostasis, but also contributes importantly to the pathophysiology of hypertension, renal disease and heart ...
Verdonk, K. (Koen)
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Clinical and Experimental Hypertension, 2022 This study was conducted to explore the effect of renal denervation (RDN) on the renin–angiotensin–aldosterone system (RAAS) in spontaneously hypertensive rats (SHRs).
Fei Qin +4 more
doaj +1 more source
Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology [PDF]
, 2016 BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer’s disease (AD). Angiotensin-
Al Mulhim, Noura S K +4 more
core +2 more sources
Therapeutic targets of renin-angiotensin system in ocular disorders
Journal of Current Ophthalmology, 2017 Purpose: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases.
Rajesh Choudhary +3 more
doaj +1 more source
ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats [PDF]
, 2010 AngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT(1) receptor (AngII type I receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia ...
Adriana K. Carmona +51 more
core +2 more sources
Thrombosis Journal, 2003 Background Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarction, neointimal hyperplasia or ...
Helbecque Nicole +5 more
doaj +1 more source