Results 51 to 60 of about 215,955 (209)

The Effects of Angiotensin II or Angiotensin 1-7 on Rat Pial Microcirculation during Hypoperfusion and Reperfusion Injury: Role of Redox Stress

Biomolecules, 2021
Renin–angiotensin systems produce angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7), which are able to induce opposite effects on circulation. This study in vivo assessed the effects induced by Ang II or Ang 1-7 on rat pial microcirculation during ...
Dominga Lapi, Maurizio Cammalleri, Massimo Dal Monte, Martina Di Maro, Mariarosaria Santillo, Anna Belfiore, Gilda Nasti, Simona Damiano, Rossella Trio, Martina Chiurazzi, Barbara De Conno, Nicola Serao, Paolo Mondola, Antonio Colantuoni, Bruna Guida   +14 more
doaj   +1 more source

Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension [PDF]

, 2009
Oxidative stress plays a critical role in the pathogenesis of hypertension. The NADPH oxidase constitutes a major source of superoxide anion in phagocytic cells, and its activation is associated with matrix metalloproteinase (MMP)-9 secretion by these ...
Beloqui, O. (Óscar), Bidegain, J. (J.), Diez-Martinez, J. (Javier), Fortuño, A. (Ana), Hermida, J. (José), Lopez-Sagaseta, J. (Jacinto), Robador, P.A. (Pablo A.), Zalba, G. (Guillermo)   +7 more
core   +1 more source

Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe kidney is easily affected by aging‐associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis is a final common pathway in most forms of progressive renal ...
Kazushi Uneda, Hiromichi Wakui, Akinobu Maeda, Kengo Azushima, Ryu Kobayashi, Sona Haku, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Masato Ohsawa, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Yoshitoshi Atobe, Akio Yamashita, Satoshi Umemura, Kouichi Tamura   +17 more
doaj   +1 more source

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue. [PDF]

PLoS ONE, 2017
Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones.
Tsuyoshi Uchiyama, Fumikazu Okajima, Chihiro Mogi, Ayaka Tobo, Shoichi Tomono, Koichi Sato   +5 more
doaj   +1 more source

Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract] [PDF]

, 2010
We recently showed that Nebivolol, a [beta]-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats.
Arnold, Shannon, DeMarco, Vincent G., Gul, Rukhsana, Sowers, James R. (James Russell), 1942-, Whaley-Connell, Adam T.   +4 more
core  

A novel mechanism of action for angiotensin-(1-7) via the angiotensin type 1 receptor [PDF]

, 2016
No abstract ...
Nicklin, Stuart A.
core   +1 more source

Impaired angiotensin II signaling in septic shock

Annals of Intensive Care
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in maintaining systemic and renal hemodynamics ...
Adrien Picod, Bruno Garcia, Dirk Van Lier, Peter Pickkers, Antoine Herpain, Alexandre Mebazaa, Feriel Azibani   +6 more
doaj   +1 more source

Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice [PDF]

, 2010
The mechanisms underlying the effect of the renin-angiotensin-aldosterone system (RAAS) inhibition on endothelial dysfunction in type 2 diabetes are incompletely understood.
Au, CL, Chen, ZY, Huang, Y, Lee, HK, Ng, CF, Tian, XY, Wong, WT, Xu, A, Yao, X   +8 more
core   +1 more source

Features of the daily profile of blood pressure, taking into account polymorphism of the angiotensin II type 1 receptor gene in patients with arterial hypertension after myocardial infarction

Medičnì Perspektivi, 2022
The article presents the results of a study of the daily blood pressure profile, taking into account the polymorphism of the angiotensin II type 1 receptor gene in patients with arterial hypertension with past myocardial infarction.
T.V. Kolesnyk , O.V. Fursa
doaj   +1 more source

Synergistic effect of angiotensin II on vascular endothelial growth factor-A-mediated differentiation of bone marrow-derived mesenchymal stem cells into endothelial cells [PDF]

, 2015
INTRODUCTION: Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly defined.
Christopher J Pelham, Devendra K Agrawal, Izuagie Ikhapoh   +2 more
core   +1 more source