Results 271 to 280 of about 134,000 (307)

Cloning and characterization of a human angiotensin II type 1 receptor

Biochemical and Biophysical Research Communications, 1992
A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe. cDNA clones were isolated which encoded a protein of 359 amino acids that shared 94.4% and 95.3% identify to rat and bovine type 1 angiotensin II receptors, respectively.
D J, Bergsma, C, Ellis, C, Kumar, P, Nuthulaganti, H, Kersten, N, Elshourbagy, E, Griffin, J M, Stadel, N, Aiyar   +8 more
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[Angiotensin II type 1 and type 2 receptor].

Nihon rinsho. Japanese journal of clinical medicine, 2009
The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
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The Angiotensin II Type 1 Receptor Antagonists

Archives of Internal Medicine, 1995
The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace All from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release.
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The Genomic Organization of Human Angiotensin II Type 1 Receptor

Biochemical and Biophysical Research Communications, 1994
As a step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT1 receptor was investigated. Comparison of the genomic DNA and cDNA sequences revealed that it consists of at least five exons. The length of the AT1 receptor gene is greater than 55 kb, and the size of the exons ranges from 59 to 2,
D F, Guo, H, Furuta, M, Mizukoshi, T, Inagami   +3 more
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Evidence for the presence of angiotensin II-type 1 receptors in brain

Brain Research Bulletin, 1990
Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177.
J K, Wamsley, W F, Herblin, M E, Alburges, M, Hunt   +3 more
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

Nature Cell Biology, 2004
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism. Without the involvement of angiotensin II, mechanical stress not only activates extracellular-signal-regulated kinases and increases ...
Yunzeng, Zou, Hiroshi, Akazawa, Yingjie, Qin, Masanori, Sano, Hiroyuki, Takano, Tohru, Minamino, Noriko, Makita, Koji, Iwanaga, Weidong, Zhu, Sumiyo, Kudoh, Haruhiro, Toko, Koichi, Tamura, Minoru, Kihara, Toshio, Nagai, Akiyoshi, Fukamizu, Satoshi, Umemura, Taroh, Iiri, Toshiro, Fujita, Issei, Komuro   +18 more
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Assessment of Inverse Agonism for the Angiotensin II Type 1 Receptor

2010
The angiotensin II (AngII) type 1 (AT₁) receptor is a seven-transmembrane G-protein-coupled receptor that plays a regulatory role in the physiological and pathological processes of the cardiovascular system. AT₁ receptor inherently shows constitutive activity even in the absence of AngII, and it is activated not only by AngII but also by AngII ...
Hiroshi, Akazawa, Noritaka, Yasuda, Shin-ichiro, Miura, Issei, Komuro   +3 more
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Role of Angiotensin II Type 1 Receptor in Angiotensin II-Induced Cytokine Production in Macrophages

Journal of Interferon & Cytokine Research, 2011
This study was aimed to investigate the regulatory effects of angiotensin II (Ang II) on the expression of Ang II type 1 (AT1) receptor and to characterize the mechanism underlying AT1 receptor promotion of inflammatory cytokines and reactive oxygen species (ROS).
Feng, Guo, Xu-Lin, Chen, Fei, Wang, Xun, Liang, Ye-Xiang, Sun, Yong-Jie, Wang   +5 more
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Regulation of angiotensin II type 1 (AT1) receptor function

Regulatory Peptides, 1999
The type 1 angiotensin receptor (AT1) mediates the important biological actions of the peptide hormone, angiotensin II (AngII), by activating an array of intracellular signaling pathways. The unique temporal arrangement and duration of AngII-stimulated signals suggests a hierarchy of post-AT1 receptor binding events that permits activation of selective
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Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition

Journal of Hypertension, 1999
This study was designed to demonstrate that the principle of molecular recognition underlying high-affinity binding of angiotensin II to the type 2 (AT2) receptor is distinct from that of the type 1 (AT1) receptor. In general, the same functional pharmacophores in hormones are used to bind and activate different subtypes of cell surface receptors ...
S, Miura, S S, Karnik
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