Results 141 to 150 of about 266,977 (390)

Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation

PPAR Research, 2019
Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions.
María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza   +8 more
doaj   +1 more source

Angiotensin II Type 2 Receptor Agonist Reduces the Inflammation and Pain Hypersensitivity in Mice with Joint Inflammatory Pain

, 2022
Wei Gao, Liang Shen, Dan-dan Long, Tingting Pan, Di Wang, Xiaoqing Chai, Shanshan Hu   +6 more
openalex   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +3 more sources

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

Frontiers in Bioscience, 2009
Angiotensin II (AngII) interacts with two receptor subtypes, AT1 and AT2, belonging to the seven transmembrane receptor superfamily. Pharmacological investigations initially suggested that AT2 receptors antagonize AT1 effects. Data from AT2 receptor transgenic and knock-out mice have not been entirely consistent with this interpretation.
Porrello, Enzo R., Delbridge, Lea M. D., Thomas, Walter G.   +2 more
openaire   +3 more sources

ZSF1 lean rats – How healthy are they?

Animal Models and Experimental Medicine, EarlyView.
This study aimed to examine the health status, specifically the physiology and myocardial, vascular, and skeletal muscle function of lean ZSF1 rats by comparing them to age‐ and sex‐matched Wistar rats. Compared to Wistar controls, ZSF1 lean rats exhibited lower body weight, but showed increased heart, and skeletal muscle mass.
Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein   +4 more
wiley   +1 more source

Decreased Expression of Angiotensin II Type 1 and Type 2 Receptors in the Brain After Long-Term Administration of Antihypertensive Drugs in Stroke-Prone Spontaneously Hypertensive Rat

Journal of Pharmacological Sciences, 2008
The present study examined the levels of Angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of ...
Yayoi Nishida, Yasuo Takahashi, Megumi Sugahara-Kobayashi, Kouichi Ishikawa, Satoshi Asai   +4 more
doaj   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation. [PDF]

Curr Opin Pharmacol, 2023
Shepherd AJ, Rice AS, Smith MT.
europepmc   +1 more source

Gene Sequencing and Tissue Expression of Unknown Isoforms of an Angiotensin II Type 2 Receptor Interacting Protein, ATIP, in the Rat [PDF]

, 2011
Michael Angus KREZEL, Linda A. Rezmann, Naghmeh Varghayee, Josefa Pete, Albert G. Frauman, Simon Nicholas Stewart LOUIS   +5 more
openalex   +1 more source

Pathophysiological Role of Caveolae in Hypertension [PDF]

, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver, Gollasch, Maik, Kaßmann, Mario, Lian, Xiaoming, Matthaeus, Claudia   +4 more
core   +2 more sources