Results 281 to 290 of about 450,783 (333)

Angiotensin II Receptor Antagonists

High Blood Pressure & Cardiovascular Prevention, 2007
Stroke is a devastating disease that heavily affects overall cardiovascular mortality and quality of life in surviving patients, and has a relevant burden on healthcare systems. Recent data derived both from large epidemiological surveys and from the analysis of events occurring in the clinical trials on hypertension, performed over the last 10 years ...
Giuliano Tocci, Francesca Giovannelli, Caterina Facciolo   +2 more
openaire   +1 more source

The Other Angiotensin II Receptor: AT2R as a Therapeutic Target.

Journal of Medicinal Chemistry, 2020
The active hormone of the renin-angiotensin system (RAS), angiotensin II (Ang II) is involved in several human diseases, driving the development and clinical use of several therapeutic drugs, mostly angiotensin I converting enzyme (ACE) inhibitors and ...
L. Juillerat-Jeanneret
semanticscholar   +1 more source

Angiotensin receptor antagonists.

Australian family physician, 2000
Angiotensin receptor antagonists are a relatively new class of cardiovascular drugs for which the clinical application has not yet been completely defined.This article reviews the pharmacology of the various angiotensin receptor antagonists available in Australia, including their mode of action, side effects and potential drug interactions.Angiotensin ...
W, Wong, L, Howes
openaire   +1 more source

Angiotensin receptor antagonists

Abstract The renin–angiotensin–aldosterone system (RAAS) is activated in patients with heart failure and contributes to many of the detrimental effects seen in these patients. Antagonists to the angiotensin II type-1 (AT1)-receptor (ARBs) provide a pharmacologically different mechanism of inhibiting the RAAS to ACE inhibitors.
Roy S. Gardner, Theresa A. McDonagh, Daniel J. Doherty, Nikki L. Walker   +3 more
openaire   +1 more source

Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects

Nature Reviews Nephrology, 2021
J. Barrera-Chimal, I. Lima-Posada, G. Bakris, F. Jaisser   +3 more
semanticscholar   +1 more source

Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding

European Journal of Pharmacology, 1999
Angiotensin II increased the inositol phosphates production (EC50 = 3.4+/-0.7 nM) in Chinese hamster ovary (CHO) cells expressing the cloned human angiotensin AT1 receptor (CHO-AT1 cells). Coincubation with angiotensin AT1 receptor antagonists produced parallel rightward shifts of the concentration-response curve without affecting the maximal response.
Fierens, F L, Vanderheyden, P M, De Backer, J P, Vauquelin, G   +3 more
openaire   +3 more sources

Angiotensin II receptor antagonists.

Arzneimittel-Forschung, 1993
The development of novel non-peptide compounds with high affinity for-angiotensin II (Ang II) receptors has greatly facilitated the subclassification of Ang II receptors into AT1- and AT2-receptor subtypes. Whereas PD 123177 (1-(4-amino-3-methylphenyl)methyl-5-diphenyl-acetyl-4,5,6,7-tetrahydro- 1H-imidazol [4,5-c]pyridine-6-carboxylic acid) is the ...
J C, van Meel, M, Entzeroth, N, Hauel, B, Narr, U, Ries, W, Wienen   +5 more
openaire   +1 more source

Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Antagonists in Atherosclerosis Prevention

Current Cardiology Reports, 2012
Maria M. Patarroyo Aponte, G. Francis
semanticscholar   +1 more source

The use of angiotensin II receptor antagonists to increase the efficacy of radiotherapy in cancer treatment.

Future Oncology, 2014
S. Hosseinimehr
semanticscholar   +1 more source

A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists

Pharmacological Reviews, 2013
M. C. Michel, C. Foster, H. Brunner, Li-sheng Liu   +3 more
semanticscholar   +1 more source