Results 81 to 90 of about 358,234 (380)

Silylation of Aryl and Alkyl Chlorides by a Seven‐Membered Dialkoxysilyl Group Si(pan)Me via an In Situ Generated Silylpotassium

Angewandte Chemie International Edition, EarlyView.
This study reveals a facile silylation protocol that enables the delivery of a stable and activatable dioxasilepanyl group, Si(pan)Me, to aryl and alkyl chlorides. Of note is the X‐ray structure of 18‐C‐6·K–Si(pan)Me, which elucidates a pivotal silylpotassium intermediate.
Kenshiro Hitoshio, Jun Shimokawa, Hideki Yorimitsu   +2 more
wiley   +1 more source

Hormone treatments in congestive heart failure

Journal of International Medical Research, 2018
The common ultimate pathological feature for all cardiovascular diseases, congestive heart failure (CHF), is now considered as one of the main public health burdens that is associated with grave implications. Neurohormonal systems play a critical role in
Lei Lei, Yuanjie Mao
doaj   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition

Circulation, 2016
Heart failure affects ≈5.7 million people in the United States alone. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, &bgr;-blockers, and aldosterone antagonists have improved mortality in patients with heart failure and reduced ...
Scott A. Hubers, N. Brown
semanticscholar   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Metabolic syndrome and angiotensin II receptor antagonists

Кардиоваскулярная терапия и профилактика, 2007
Aim. To investigate the effects of angiotensin II receptor antagonist irbesartan on blood pressure (BP), tissue insulin sensitivity, carbohydrate and lipid metabolism, cerebral perfusion parameters in patients with arterial hypertension (AH), metabolic ...
K. M. Mamyrbayeva, V. B. Mychka, V. B. Sergienko, I. E. Chazova   +3 more
doaj  

HYPERVISCOSITY SYNDROME IN ARTERIAL HYPERTENSION AND HEMORHEOLOGICAL EFFECTS OF ANTIHYPERTENSIVE DRUGS

Российский кардиологический журнал, 2016
Current study briefly shows the pathological changes of blood rheological properties in arterial hypertension and the impact of main rheological parameters is discussed (hematocrit, plasma viscosity, aggregation, erythrocyte deformity) on the development
A. Yu. Shamanaev, O. I. Aliev, A. M. Anishchenko, A. V. Sidekhmenova, M. B. Plotnikov   +4 more
doaj   +1 more source

A hydrophobic-interaction-based mechanism trigger docking between the SARS CoV 2 spike and angiotensin-converting enzyme 2 [PDF]

arXiv, 2020
A recent experimental study found that the binding affinity between the cellular receptor human angiotensin converting enzyme 2 (ACE2) and receptor-binding domain (RBD) in spike (S) protein of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more than 10-fold higher than that of the original severe acute respiratory syndrome ...
arxiv  

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal

Acta Médica Portuguesa, 2019
Introduction: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence.
Miguel Bigotte Vieira, João Sérgio Neves, Rute Baeta Baptista, Lia Leitão, Catarina Viegas Dias, Ricardo Vicente, Nilton Nascimento, Celina Costa Leite, Isabel Rocha, Rita Magriço   +9 more
doaj   +1 more source