Results 81 to 90 of about 78,683 (358)

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Metabolic syndrome and angiotensin II receptor antagonists

Кардиоваскулярная терапия и профилактика, 2007
Aim. To investigate the effects of angiotensin II receptor antagonist irbesartan on blood pressure (BP), tissue insulin sensitivity, carbohydrate and lipid metabolism, cerebral perfusion parameters in patients with arterial hypertension (AH), metabolic ...
K. M. Mamyrbayeva, V. B. Mychka, V. B. Sergienko, I. E. Chazova   +3 more
doaj  

Blood pressure control versus atrial fibrillation management in stroke prevention [PDF]

, 2015
Hypertension is one of the major risk factors for atrial fibrillation which in turn is the most prevalent concomitant condition in hypertensive patients. While both these pathological conditions are independent risk factors for stroke, the association of
Sada, Lidia, Savoia, Carmine, Volpe, Massimo   +2 more
core   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

HYPERVISCOSITY SYNDROME IN ARTERIAL HYPERTENSION AND HEMORHEOLOGICAL EFFECTS OF ANTIHYPERTENSIVE DRUGS

Российский кардиологический журнал, 2016
Current study briefly shows the pathological changes of blood rheological properties in arterial hypertension and the impact of main rheological parameters is discussed (hematocrit, plasma viscosity, aggregation, erythrocyte deformity) on the development
A. Yu. Shamanaev, O. I. Aliev, A. M. Anishchenko, A. V. Sidekhmenova, M. B. Plotnikov   +4 more
doaj   +1 more source

Treatment of Patients with COVID-19 and Concomitant Cardiovascular Diseases: Do not Forget About the Principles of Evidence-based Medicine

Рациональная фармакотерапия в кардиологии, 2020
The recent discussion about the dangers of using angiotensin-converting-enzyme (ACE) inhibitors and angiotensin II receptor antagonists (ARA) in patients with COVID-19 is analyzed in the article.
S. Yu. Martsevich
doaj   +1 more source

Ace inhibition and cardiovascular mortality and morbidity in essential hypertension: The end of the search or a need for further investigations? [PDF]

, 2016
Scientific evidence currently available supports the concept that renin-angiotensin blockade with angiotensin converting enzyme inhibitors as a first-line treatment exhibits in arterial hypertension beneficial effects in the prevention of mortality and ...
Coca, Antonio, Ruilope, Luis M., Volpe, Massimo, Waeber, Bernard   +3 more
core  

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

RENIN-ANGIOTENSIN PROFILE AND COMPARATIVE EFFECTIVENESS OF FIRST-LINE MEDICATIONS IN MONOTHERAPY OF ESSENTIAL ARTERIAL HYPERTENSION

Российский кардиологический журнал, 2010
The study investigated the rational antihypertensive therapy in 966 patients with essential arterial hypertension (AH) and various renin-angiotensin blood profiles.
Sh. V. Akhadov, G. R. Ruzbanova, G. S. Molchanova   +2 more
doaj