Synthetic nanobodies as angiotensin receptor blockers [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance The G protein-coupled receptor (GPCR) family is responsible for regulating much of human physiology, and GPCRs have become the most successful target class for drug development. Although many biologics have gained clinical approval, GPCR-targeted drugs remain almost exclusively small molecules, and developing GPCR ...
Conor McMahon +9 more
openaire +2 more sources
Lack of Association Between Neurohormonal Blockade and Survival in Transthyretin Cardiac Amyloidosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Despite the belief that heart failure therapies are not effective in transthyretin cardiac amyloidosis, data are limited. We tested the association of neurohormonal blockade use with survival.
Richard K. Cheng +6 more
doaj +1 more source
Fimasartan: A new armament to fight hypertension
Journal of Family Medicine and Primary Care, 2019 Hypertension is a major public health problem of modern era. Fimasartan is a new Angiotensin Receptor Blocker approved for treatment of hypertension.
Akshyaya Pradhan +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Trastuzumab is associated with the risk of cardiotoxicity. Here, we aim to explore interventions for preventing trastuzumab-related cardiotoxic effects in breast cancer patients.Methods: A systematic review was performed including trials of ...
Xinyi Li +5 more
doaj +1 more source
Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]
, 2016 Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian +11 more
core +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Knowledge of real‐world antihypertensive use is limited to prevalent hypertension, limiting our understanding of how treatment evolves and its contribution to persistently poor blood pressure control. We sought to characterize antihypertensive
Steven M. Smith +8 more
doaj +1 more source
Influence of angiotensin II receptor blocker combination tablet prescription on drug number and cost
SAGE Open Medicine, 2014 Objectives: Combination therapy using an angiotensin II receptor blocker is expected to promote medication adherence and alleviate economic burden among patients by reducing the number of drugs taken, and thereby to lower associated medical costs. In the
Hitomi Teramachi +8 more
doaj +1 more source
Evaluation of prescription pattern of anti - Hypertensive drugs in Urban population of Hyderabad
MRIMS Journal of Health Sciences, 2014 Knowledge of existing prescription patterns in the treatment of hypertension can provide useful information for improving clinical practice in this field.
M Jamuna Rani, G Jyothsna, Rohit Singh
doaj +1 more source
Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]
, 2004 <p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C. +5 more
core +1 more source
Intraoperative angioedema induced by angiotensin II receptor blocker: a case report
Patient Safety in Surgery, 2018 Background Angiotensin II receptor blockers are a class of antihypertensive agent that is developed to exclude the adverse effects of angiotensin converting enzyme inhibitors.
Ala”a Alhowary +3 more
doaj +1 more source