Results 31 to 40 of about 106,446 (312)

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function [PDF]

, 2014
<b>Objective:</b><p></p> Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies.
Adlam, Cai, Calhoun, Chacko, Chandran, DAgostino, Dai, Dai, Dikalova, Doughan, Evans, Flores-Munoz, Flores-Munoz, Gane, Graham, Graham, Gutierrez, Halliwell, Jalil, Jeffs, Landmesser, London, Lowes, Mercer, Messerli, Murphy, Murphy, Nakagami, Nakamura, Nozoe, Qin, Rajagopalan, Roman, Ross, Snow, Watkins, Winterbourn, Yang, Yasunari, Zhang, Zhang, Zorov   +41 more
core   +1 more source

Beta-blocker under-use in COPD patients [PDF]

, 2017
Background: Cardiovascular (CVS) comorbidities are common in COPD and contribute significantly to morbidity and mortality, especially following acute exacerbations of COPD (AECOPD).
Lavender, Melanie, Lim, Kuan Pin, Loughrey, Sarah, Musk, Michael, Wrobel, Jeremy P   +4 more
core   +2 more sources

Eicosapentaenoic and Docosahexaenoic Acids Attenuate Progression of Albuminuria in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAlbuminuria is a marker of inflammation and an independent predictor of cardiovascular morbidity and mortality. The current study evaluated whether eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation attenuates ...
Tarec K. Elajami, Abdulhamied Alfaddagh, Dharshan Lakshminarayan, Michael Soliman, Madhuri Chandnani, Francine K. Welty   +5 more
doaj   +1 more source

Angiotensin receptor blockers for heart failure [PDF]

Cochrane Database of Systematic Reviews, 2012
Chronic heart failure (HF) is a prevalent world-wide. Angiotensin receptor blockers (ARBs) are widely prescribed for chronic HF although their role is controversial.To assess the benefit and harm of ARBs compared with ACE inhibitors (ACEIs) or placebo on mortality, morbidity and withdrawals due to adverse effects in patients with symptomatic HF and ...
Balraj S, Heran, Vijaya M, Musini, Ken, Bassett, Rod S, Taylor, James M, Wright   +4 more
openaire   +2 more sources

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]

, 2019
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Hillege, Hans L., Lam, Carolyn S. P., Lang, Chim C., Metra, Marco, Nauta, Jan F., Ng, Leong L., Romaine, Simon P. R., Sama, Iziah E., Samani, Nilesh J., Ter Maaten, Jozine M., Tromp, Jasper, van der Meer, Peter, van Veldhuisen, Dirk J., Voors, Adriaan A., Woolley, Rebecca J., Zannad, Faiez   +18 more
core   +5 more sources

Angiotensin receptor blockers [PDF]

Journal of Hypertension, 2013
Angiotensin receptor blockers (ARBs) are commonly used antihypertensive medication with several other additional proven benefits. Recent controversy on association of lung cancer and other solid malignancy with the use of ARBs is concerning, although the follow-up studies have shown no such association.We used data from the Department of Veterans ...
Gowtham Adamane, Rao, Joshua R, Mann, Azza, Shoaibi, Sachin G, Pai, Matteo, Bottai, Shawn Scott, Sutton, Kathlyn Sue, Haddock, Charles Lee, Bennett, James R, Hebert   +8 more
openaire   +2 more sources

Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters

Journal of Pharmacological Sciences, 2010
Hyperuricemia is currently recognized as a risk factor for cardiovascular diseases. It has been reported that the angiotensin II–receptor blocker (ARB) losartan decreases serum uric acid level.
Makiko Nakamura, Naohiko Anzai, Promsuk Jutabha, Hiroyuki Sato, Hiroyuki Sakurai, Kimiyoshi Ichida   +5 more
doaj   +1 more source

Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors. [PDF]

PLoS ONE, 2014
INTRODUCTION: Recently, we could show that angiotensin II, the reactive peptide of the blood pressure-regulating renin-angiotensin-aldosterone-system, causes the formation of reactive oxygen species and DNA damage in kidneys and hearts of hypertensive ...
Susanne Brand, Kerstin Amann, Philipp Mandel, Anna Zimnol, Nicole Schupp   +4 more
doaj   +1 more source

Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction [PDF]

, 2011
<b>Background</b> Meta-analysis of small trials suggests that pharmacist-led collaborative review and revision of medical treatment may improve outcomes in heart failure.<p></p> <b>Methods and results</b> We studied
Forsyth, P., Greenlaw, N., Jhund, P.S., Lowrie, R., Mair, F.S., McConnachie, A., McMurray, J.J.V., Rae, B.   +7 more
core   +1 more source

Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. [PDF]

PLoS ONE, 2014
Peroxisome proliferator activated receptor γ (PPARγ) has been reported to play a protective role in the vasculature; however, the underlying mechanisms involved are not entirely known.
Maria Alicia Carrillo-Sepulveda, Henry L Keen, Deborah R Davis, Justin L Grobe, Curt D Sigmund   +4 more
doaj   +1 more source