Results 1 to 10 of about 180,575 (186)

Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu, Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy, Robert M. Carey, Ceereena Ubaida‐Mohien, Brian O'Rourke, Luigi Ferrucci, David A. Bennett, Jeremy Walston, Peter Abadir   +12 more
doaj   +2 more sources

Angiotensin receptors and neuropathic pain [PDF]

PAIN Reports, 2021
. Growing evidence implicates the renin–angiotensin system (RAS) in multiple facets of neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS peptide, Angiotensin II (Ang II), and its receptors, namely type 1 (AT1R) and
Mihály Balogh, Clarissa Aguilar, Nicholas T. Nguyen, Andrew J. Shepherd   +3 more
doaj   +2 more sources

Receptors | Angiotensin Receptors [PDF]

Encyclopedia of Biological Chemistry III, 2021
The renin-angiotensin-aldosterone system (RAS) is a vital hormone-receptor system that regulates cardiovascular and renal functions. In this article, we discuss exciting new findings in the RAS field. Recently solved active state crystal structures of Angiotensin II type 1 (AT1R) and type 2 receptor (AT2R) helped in understanding receptor activation ...
Pardhi, Triveni R., Karnik, Sadashiva S.
europepmc   +2 more sources

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System [PDF]

Molecules, 2022
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurring ...
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas   +7 more
doaj   +2 more sources

Localization and Expression of Renin–Angiotensin System Receptors in Lung from Transplant Patients: A Case-Control Study [PDF]

Biomedicines
Objective: We aimed to assess the expression and localization of renin-angiotensin system (RAS) receptors in lung tissue and the plasma concentration of related peptides in IPF patients. Materials and Methods: This case–control study involved 19 patients
Andresa Thomé Silveira, Lucas Sagrillo Fagundes, Juliane Flor, Isabel Amaral Martins, Laura Bastos Otero, Laura Tibola Marques da Silva, Lorenzo Santana Maciel, Sarah Eller, Giuliano Rizzotto Guimarães, Fabíola Adelia Perin, Márcia Rosângela Wink, Katya Rigatto   +11 more
doaj   +2 more sources

Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats [PDF]

, 2014
Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to ...
Abdala, Ana Paula, Mill, José Geraldo, Moraes, Davi José de Almeida, Passamani, Luciana Mesquita, Paton, Julian Francis Richmond, Sampaio, Karla Nívea   +5 more
core   +17 more sources

Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]

Farmacja Polska, 2021
The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska, Karolina Zając, Klaudia Zargaryan, Jolanta Barbara Zawilska   +3 more
doaj   +1 more source

Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain

Molecules, 2021
The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the effectiveness of opioids. Nevertheless, dose escalation is required to maintain their analgesia, which,
Kornél Király, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, Susanna Fürst, Mahmoud Al-Khrasani   +11 more
doaj   +1 more source

Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors

International Journal of Nephrology, 2022
The sympathetic and renin-angiotensin systems (RAS) are two critical regulatory systems in the kidney which affect renal hemodynamics and function. These two systems interact with each other so that angiotensin II (Ang II) has the presynaptic effect on ...
Hajaralsadat Hosseini-Dastgerdi, Fatemeh Kharazmi, Ali-Asghar Pourshanazari, Mehdi Nematbakhsh   +3 more
doaj   +1 more source

Estrogen Metabolite 2-Methoxyestradiol Attenuates Blood Pressure in Hypertensive Rats by Downregulating Angiotensin Type 1 Receptor

Frontiers in Physiology, 2022
The therapeutic potential of 2-Methoxyestradiol (2ME2) is evident in cardiovascular disease. Our laboratory has previously demonstrated the mechanism involved in the 2ME2 regulation of angiotensin type 1 receptor (AT1R) in vitro. However, 2ME2 regulation
Yong Zhang, Benard O. Ogola, Laxmi Iyer, Vardan T. Karamyan, Thomas Thekkumkara   +4 more
doaj   +1 more source