Results 1 to 10 of about 21,818 (144)
Desensitization of angiotensin receptor function
Kidney International, 1994 Angiotensin II is an eight amino acid peptide which plays a major role in the regulation of cardiovascular homeostasis. The physiologic effects of angiotensin (Ang) II are mediated by a G-protein coupled receptor, termed AT1, which activates phospholipase C.
Victor J. Dzau +2 more
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Receptors | Angiotensin Receptors
, 2021 The renin-angiotensin-aldosterone system (RAS) is a vital hormone-receptor system that regulates cardiovascular and renal functions. In this article, we discuss exciting new findings in the RAS field. Recently solved active state crystal structures of Angiotensin II type 1 (AT1R) and type 2 receptor (AT2R) helped in understanding receptor activation ...
Triveni R. Pardhi, Sadashiva S. Karnik
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Angiotensin receptors and neuropathic pain
PAIN Reports, 2021 Abstract Growing evidence implicates the renin–angiotensin system (RAS) in multiple facets of neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS peptide, Angiotensin II (Ang II), and its receptors, namely type 1 (AT1R) and type 2 (AT2R).
Nicholas T. Nguyen +3 more
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Angiotensin Receptors in the Brain [PDF]
Pharmacology & Toxicology, 1995 Abstract:Angiotensin receptors have recently become a focus of scientific interest due to the recent development of specific receptor ligands which allow to distinguish between various angiotensin II receptor subtypes, notably the angiotensin II type 1 receptor (AT1) and angiotensin II type 2 receptor (AT2).
Susanne Höhle +4 more
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Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6 [PDF]
CHIN.PHYS.LETT. Vol.38, No.1(2021)018701 Express Letter, 2021 The spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health crisis. The binding affinity of SARS-CoV-2 (in particular the receptor binding domain, RBD) to its receptor angiotensin converting enzyme 2 (ACE2) and the antibodies is of great importance in ...
arxiv +1 more source
In-Silico evidence for two receptors based strategy of SARS-CoV-2 [PDF]
Front. Mol. Biosci., 09 June 2021, 2020 We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and general procedure, based on the representation of the molecular iso-electron density surface in terms of 2D Zernike polynomials, allows the rapid and quantitative assessment of ...
arxiv +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms [PDF]
St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17, 2019 G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be ...
arxiv +1 more source
Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19 [PDF]
Biomolecules, 2021 Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the presence and absence of the Arg guanidino group occupying position 2 of Ang II.
John Matsoukas +8 more
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Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses [PDF]
Pharmacol Res, 136:108-20 (2018), 2019 Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as
arxiv +1 more source