Results 241 to 250 of about 180,674 (285)

Repurposing Renin-Angiotensin System Drugs for the Treatment of Audiovestibular Disorders. [PDF]

J Clin Med
Podhajsky G, Marla KS, Marticoff AP, Nguyen K, Kempton T, Salehpour S, Duffy C, Bennion DM.   +7 more
europepmc   +1 more source

A key role of AT_1a receptors and Na⁺/H⁺ exchanger 3 in the proximal tubules in angiotensin II-induced and two-kidney, one-clip Goldblatt hypertension. [PDF]

Am J Physiol Renal Physiol
Li XC, Hassan R, Zhuo JL.
europepmc   +1 more source

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Angiotensin receptors

Trends in Pharmacological Sciences, 1997
The octapeptide angiotensin II, the potent effector molecule of the renin-angiotensin system, has been implicated in the pathology of hypertension, in cardiovascular diseases like cardiac left ventricular hypertrophy and in structural alterations of the heart such as post-infarct remodelling.The development of highly selective angiotensin II receptor ...
T, Unger, O, Chung, T, Csikos, J, Culman, S, Gallinat, P, Gohlke, S, Höhle, S, Meffert, M, Stoll, U, Stroth, Y Z, Zhu   +10 more
openaire   +3 more sources

Angiotensin Receptors - Affinity and Beyond

Clinical Science, 2022
Abstract This commentary on the article “Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors” by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297–303. https://doi.org/10.1042/CS20110036) summarises the main findings of the study, followed by a discussion of the findings and their relevance for
Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings   +2 more
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Angiotensin II Receptor Heterogeneity

American Journal of Hypertension, 1991
The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of our earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes.
William F. Herblin, Andrew T. Chiu, Dale E. McCall, Robert J. Ardecky, David J. Carini, John V. Duncia, Lori J. Pease, Pancras C. Wong, Ruth R. Wexler, Alexander L Johnson, Pieter B.M.W.M. Timmermans   +10 more
openaire   +2 more sources

Human angiotensin receptor subtypes

Current Opinion in Nephrology and Hypertension, 1994
The rapid expansion of our knowledge of angiotensin receptors has been led by the development of subtype-specific angiotensin II receptor antagonists and by the cloning and sequencing of the AT1 receptor in angiotensin II. Although some actions of angiotensin II have been attributed to AT2 subtype receptors, the importance of these binding sites ...
Ronald D. Smith, &NA; Pieter, &NA; Timmermans   +2 more
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Tachyphylaxis and angiotensin receptors

General Pharmacology: The Vascular System, 1976
Angiotensin tachyphylaxis was studied in the isolated guinea pig ileum under isometric conditions. 2. In tachyphylactic organs, the initial phasic response to angiotensin was abolished, while the tonic component of the response became faster in its onset and in its reversal (relaxation). 3.
Paiva, T. B., Aboulafia, J., Nouailhetas, VLA, Paiva, ACM   +3 more
openaire   +3 more sources