Results 51 to 60 of about 21,917 (243)

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Day‐to‐day fasting plasma glucose variability on the short‐term prognosis of ST‐segment elevation myocardial infarction: A retrospective cohort study

Clinical Cardiology, Volume 45, Issue 12, Page 1246-1254, December 2022., 2022
Abstract Background and Hypothesis Glycemic variability in one fact that explain the differences in cardiovascular outcomes. The short‐term fasting plasma glucose (FPG) variability may have an on major adverse cardiovascular events (MACE) in type 2 diabetes mellitus (T2DM) patients with ST‐segment elevation myocardial infarction (STEMI).
Ming Yi, Qing Cao, Wen‐hui Tang, Qiang Liu, Xiao Ke   +4 more
wiley   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

The efficacy of nitroglycerin to prevent radial artery spasm and occlusion during and after transradial catheterization: A systematic review and meta‐analysis of randomized controlled trials

Clinical Cardiology, Volume 45, Issue 12, Page 1171-1183, December 2022., 2022
Abstract Radial artery spasm (RAS) is the most common cause of transradial access site crossover and is a common intra‐procedural complication. RAS incidence can lead to radial artery occlusion (RAO) postprocedure, preventing the radial artery as a future access site.
Basel Abdelazeem, Mohamed T. Abuelazm, Sarya Swed, Mohamed Gamal, Mostafa Atef, Mohamed A. Al‐Zeftawy, Muhammad A. Noori, Anthony Lutz, Annabelle S. Volgman   +8 more
wiley   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

The mortality for the implantable cardiac defibrillator in nonischemic cardiomyopathy: An updated systematic review and meta‐analysis

Clinical Cardiology, Volume 45, Issue 12, Page 1163-1170, December 2022., 2022
Abstract The implantable cardiac defibrillator (ICD) is common for the management of nonischemic cardiomyopathy (NICM). Mortality is a crucial issue for patients with NICM. We can understand the mortality events of ICD versus medicine treatment via a systemic review and meta‐analysis of randomized clinical trials.
Wenfeng He, Cheng Xue, Jiankang Zheng, Zhuang Shuai   +3 more
wiley   +1 more source

Review of COVID-19 Antibody Therapies [PDF]

arXiv, 2020
Under the global health emergency caused by coronavirus disease 2019 (COVID-19), efficient and specific therapies are urgently needed. Compared with traditional small-molecular drugs, antibody therapies are relatively easy to develop and as specific as vaccines in targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and thus attract ...
arxiv  

Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies

AGING MEDICINE, EarlyView.
This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang, Yu‐Qing Ni, You‐Shuo Liu   +2 more
wiley   +1 more source

A remote hypertension management program clinical algorithm

Clinical Cardiology, Volume 45, Issue 12, Page 1147-1162, December 2022., 2022
Abstract Introduction Hypertension is the leading risk factor for death, affecting over one billion people worldwide, yet control rates are poor and stagnant. We developed a remote hypertension management program that leverages digitally transmitted home blood pressure (BP) measurements, algorithmic care pathways, and patient–navigator communications ...
Hunter Nichols, Christopher P. Cannon, Benjamin M. Scirica, Naomi D. L. Fisher   +3 more
wiley   +1 more source

Angiotensin Receptor Blockers [PDF]

Circulation, 2003
Angiotensin receptor blockers (also known as ARBs) are a class of medications that are widely used by patients with high blood pressure, kidney disease, and heart failure. This article provides information for patients who receive this type of medication.
openaire   +2 more sources