Results 111 to 120 of about 215,468 (339)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity

Scientific Reports
Cardiovascular-kidney-metabolic health reflects the interactions between metabolic risk factors, chronic kidney disease, and the cardiovascular system. A growing body of literature suggests that metabolic syndrome (MetS) in individuals of normal weight ...
Jonathan P. Mochel, Jessica L. Ward, Thomas Blondel, Debosmita Kundu, Maria M. Merodio, Claudine Zemirline, Emilie Guillot, Ryland T. Giebelhaus, Paulina de la Mata, Chelsea A. Iennarella-Servantez, April Blong, Seo Lin Nam, James J. Harynuk, Jan Suchodolski, Asta Tvarijonaviciute, José Joaquín Cerón, Agnes Bourgois-Mochel, Faiez Zannad, Naveed Sattar, Karin Allenspach   +19 more
doaj   +1 more source

The angiotensin-(1-7)/mas axis counteracts angiotensin II-dependent and -independent pro-inflammatory signaling in human vascular smooth muscle cells [PDF]

, 2016
Background and Aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases.
Alejandra Romero, Carlos F Sánchez-Ferrer, Concepción Peiró, Elena Cercas, Laura A Villalobos, Mariella Ramos-González, Raffaele Carraro, Raffaele Carraro, Susana Vallejo, Tania Romacho, Álvaro San Hipólito   +10 more
core   +4 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar rats [PDF]

, 2015
Novel peptides with antihypertensive effects in SHR rats have previously been identified in lactoferrin (LF) hydrolysates. To investigate their in vivo antihypertensive mechanism, we have assessed the blood pressure lowering effects of two of these LF ...
Castelló-Ruiz, María, García Tejedor, Aurora, Gimeno Alcañiz, José Vicente, Manzanares, Paloma, Salom, Juan B.   +4 more
core   +1 more source

Beyond right or wrong: How partial credit scoring on multiple‐choice questions improves student performance and assessment perceptions

British Journal of Clinical Pharmacology, EarlyView.
Aims In this study, we examined the effects of assigning partial credit to selected answer choices on student performance and perceptions in a pharmacology course using Type A multiple‐choice questions (MCQs). Methods Partial credit scoring was incorporated into quizzes and exams in a 10‐week pharmacology course for postbaccalaureate premedical ...
Stephen D. Schneid, Chris Armour, Katharina Brandl   +2 more
wiley   +1 more source

Angiostatic activity of human plasminogen fragments is highly dependent on glycosylation [PDF]

, 2010
To assess the importance of carbohydrate moieties to the anti-angiogenic activity of plasminogen fragments, we cloned the fragment corresponding to amino acids Val(79) to Thr(346) (Kint3-4) that presents the three glycosylation sites.
Araujo, Ronaldo Carvalho, Barcelos, Luciola Silva, Cardoso, Valbert Nascimento, Gomes, Maria Aparecida, Higuchi, Debora Ayame, Lima, Mercia Paula, Paz Lopes, Mirian Teresa, Pesquero, Joao Bosco, Pesquero, Jorge Luiz, Santos, Ivan Carlos, Silbiger, Vivian Nogueira, Teixeira, Mauro Martins   +11 more
core   +2 more sources

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

The effects of central angiotensin II and its specific blockers on nociception: Possible interactions with oxidative stress status [PDF]

Journal of Medical Biochemistry, 2013
It has already been demonstrated that a complete brain renin angiotensin system (RAS) exists distinctly separate from the peripheral system and is implicated in complex functions such as memory, emotional responses and pain. Regarding the implications of
Arcan Oana, Ciobica Alin, Bild Walther, Stoica Bogdan, Hritcu Lucian, Cojocaru Dumitru   +5 more
doaj  

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source