Results 81 to 90 of about 2,480 (301)
Humanized immune system animal models and their recent applications
Animal Models and Experimental Medicine, EarlyView.In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli +6 more
wiley +1 more source
, 2006 Noradrenaline (NA) released by dendrites of locus coeruleus (LC) neurons controls LC neuron activity, and hence, NA released from noradrenergic fibers in terminal fields. NA synthesis is dependent on tyrosine hydroxylase (TH), whose dendritic presence is
Ogier, Michaël +5 more
core
Animal Models and Experimental Medicine, EarlyView.In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang +12 more
wiley +1 more source
Distribution of a novel binding site for angiotensins II and III in mouse tissues
, 2010 A novel binding site for angiotensins II and III that is unmasked by parachloromercuribenzoate has been reported in rat, mouse and human brains. Initial studies of this binding site indicate that it is not expressed in the adrenal, liver or kidney of the
Speth, Robert C +2 more
core +1 more source
The renin-angiotensin system in the hypertensive kidney: clinical studies in patients with essential hypertension, fibromuscular dysplasia, and the atherosclerotic renal artery stenosis [PDF]
, 2016 The renin-angiotensin system is one of the most important systems for regulating blood pressure. Various signal compounds (angiotensins) play a crucial role in this system.
van Twist, Daan
core +1 more source
Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile
Annals of Neurology, EarlyView.Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale +17 more
wiley +1 more source
Plasma angiotensins and human forearm circulation: effects of sympatho-adrenal activation
, 1997 Complex interactions appear to exist between the renin-angiotensin system and sympathetic neurotransmission, and sympathetic activity may influence local angiotensin II formation.
Lindqvist, M. +4 more
core +1 more source
The 9+ month marathon: How pregnancy may have shaped human endurance capacities
The Anatomical Record, EarlyView.Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley +1 more source