Results 131 to 140 of about 4,420 (152)

Triglyceride-Rich Lipoprotein Metabolism and Cardiovascular Risk in Diabetes: Bedside to Bench to Bedside. [PDF]

Circ Res
Ginsberg HN, Bornfeldt KE.
europepmc   +1 more source

How ANGPTL3 Inhibition Will Help Our Clinical Practice?

Current Atherosclerosis Reports, 2023
Purpose of review: This review aims to summarize the most recently published literature highlighting the potential of pharmacological inhibition of ANGPTL3 in treating patients suffering from dyslipidemias.
Alessia di Costanzo, Simone Bini, Laura D'Erasmo   +2 more
exaly   +2 more sources

Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
OBJECTIVE: Angiopoietin-like 3 (Angptl3) is a regulator of lipoprotein metabolism at least by inhibiting lipoprotein lipase activity. Loss-of-function mutations in ANGPTL3 cause familial combined hypolipidemia through an unknown mechanism. APPROACH AND
Marianna Maranghi, Daniel Rader, Katariina Öörni   +2 more
exaly   +2 more sources

Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia

International Journal of Molecular Sciences, 2021
Dyslipidemia is characterized by increasing plasma levels of low-density lipoprotein-cholesterol (LDL-C), triglycerides (TGs) and TG-rich lipoproteins (TGRLs) and is a major risk factor for the development of atherosclerotic cardiovascular disorders ...
Je-Wen Liou, Ching-Yen Lin, Jui-Hung Yen
exaly   +2 more sources

The role of ANGPTL3 in controlling lipoprotein metabolism [PDF]

Endocrine, 2016
Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids.
Matti Jauhiainen
exaly   +2 more sources

Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia [PDF]

Journal of Biomedical Research, 2019
Three members of the angiopoietin-like (ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8- are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of ...
Patrizia Tarugi, Stefano Bertolini, Sebastiano Calandra   +2 more
exaly   +2 more sources

Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation

Atherosclerosis, 2020
Background and aims: Statins suppress hepatic mRNA expression of ANGPTL3 encoding angiopoietin-like 3 in healthy subjects, but it is unknown if plasma ANGPTL3 concentrations are affected by statins prescribed to hypercholesterolemic patients in clinical ...
Tycho R Tromp, Erik Stroes, Laurens F Reeskamp   +2 more
exaly   +2 more sources

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Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Proceedings of the National Academy of Sciences of the United States of America, 2021
Qiaobing Xu, Zhongfeng Ye, Xuewei Zhao
exaly