Angiopoietin-like Proteins and Lipoprotein Lipase: The Waltz Partners That Govern Triglyceride-Rich Lipoprotein Metabolism? Impact on Atherogenesis, Dietary Interventions, and Emerging Therapies. [PDF]
J Clin MedGugliucci A.
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Unraveling the physiological impact of ANGPTL8 loss-of-function variants in humans
Scientific ReportsArkan Abadi +28 more
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The determinants of leptin, angiopoietin like 8, and thyroid hormones levels in Saudi females with type 2 diabetes mellitus: A retrospective study. [PDF]
Medicine (Baltimore)Binjawhar D, Mohammedsaeed W.
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New exploration on pathogenesis and early diagnosis of gestational diabetes.
World J Clin CasesBai H.
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Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy
International Journal of Molecular Sciences, 2023 Diabetic nephropathy (DN) is a complicated condition related to type 2 diabetes mellitus (T2D). ANGPTL8 is a hepatic protein highlighted as a risk factor for DN in patients with T2D; additionally, recent evidence from DN studies supports the involvement ...
Mohamed Abu-Farha +2 more
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ANGPTL8 in cardio-metabolic diseases
Clinica Chimica Acta, 2021Dyslipidemia has been identified as an important factor in obesity, diabetes mellitus, and cardiovascular diseases (CVD), grouped as cardio-metabolic disorder diseases. Accordingly, dyslipidemia has become a major determinant in health worldwide.
Xin Su, Ye Cheng
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Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways [PDF]
Genomics, 2017 ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature.
Amnah Siddiqa +2 more
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Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
American Journal of Physiology-Endocrinology and Metabolism, 2021Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues.
Kelli L. Sylvers-Davie +1 more
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ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia
Journal of Clinical Lipidology, 2021The role of ANGPTL3 and ANGPTL8 in lipid regulation in patients with very high levels of HDL-cholesterol and triglyceride is unknown.We examined plasma levels of ANGPTL3 and ANGPTL8 in subjects with hyperalphalipoproteinemia (HALP) and in those with severe hypertriglyceridemia (HTG).Plasma ANGPTL3 and ANGPTL8 levels were measured by ELISA in 320 ...
Chatchon Kaewkrasaesin +3 more
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ANGPTL8 (betatrophin) role in diabetes and metabolic diseases
Diabetes/Metabolism Research and Reviews, 2017SummaryDiabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation.
Mohamed Abu-Farha, Jehad Abubaker
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