Results 151 to 160 of about 1,534 (183)

Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8

American Journal of Physiology-Endocrinology and Metabolism, 2021
Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues.
Kelli L. Sylvers-Davie, Brandon S. J. Davies   +1 more
openaire   +2 more sources

Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways [PDF]

Genomics, 2017
ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature.
Amjad Ali, Jamil Ahmad, Amnah Siddiqa
exaly   +3 more sources

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

Diabetes/Metabolism Research and Reviews, 2017
SummaryDiabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation.
Mohamed Abu-Farha, Jehad Abubaker
exaly   +3 more sources

ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia

Journal of Clinical Lipidology, 2021
The role of ANGPTL3 and ANGPTL8 in lipid regulation in patients with very high levels of HDL-cholesterol and triglyceride is unknown.We examined plasma levels of ANGPTL3 and ANGPTL8 in subjects with hyperalphalipoproteinemia (HALP) and in those with severe hypertriglyceridemia (HTG).Plasma ANGPTL3 and ANGPTL8 levels were measured by ELISA in 320 ...
Chatchon Kaewkrasaesin, Waralee Chatchomchuan, Suwanna Muanpetch, Weerapan Khovidhunkit   +3 more
openaire   +2 more sources

Decreased circulating levels of ANGPTL8 in Graves’ disease patients [PDF]

Hormones, 2019
Angiopoietin-like protein 8 (ANGPTL8), a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. However, little is as yet known as to whether circulating ANGPTL8 levels are altered in thyroid dysfunction.
Li Zhao, Yanyan Li, Guoyue Yuan
exaly   +3 more sources

ANGPTL8 regulates adipocytes differentiation and adipogenesis in bovine

Gene, 2019
The formation of bovine adipose tissue involves complex developmental and physiological processes that play a vital role in determining the quality of beef; however, the regulatory mechanisms are largely unknown. Angiopoietin-like protein 8 (ANGPTL8) has been reported to be involved in the development of adipose tissue; however, the mechanism of ...
Xuefeng, Wei, Shuang, Han, Shuzhe, Wang, Quizhi, Zheng, Xin, Li, Jie, Du, Jinhui, Zhao, Fei, Li, Yun, Ma   +8 more
openaire   +2 more sources

Analysis of ANGPTL8 promoter activity and screening of related transcription factors in bovine

Gene, 2021
Analysing the molecular regulation mechanism of fat deposition in yellow cattle can provide a theoretical basis for the breeding of excellent beef cattle. ANGPTL8 (angiopoietin-like protein 8) promotes the formation of lipid droplets during adipocyte differentiation.
Xuefeng, Wei, Yunchang, Zhu, Jie, Du, Xiaojie, Ma, Xue, Zhao, Yaoyao, Ma, Shuang, Han, Yun, Ma   +7 more
openaire   +2 more sources

The regulation of endothelial lipase and lipoprotein lipase by ANGPTL3 and ANGPTL8

2022
Low levels of circulating high density lipoproteins (HDL) and high levels of plasma triglycerides (TG) are risk factors for cardiac disease and atherosclerosis. The liver-expressed protein angiopoietin-like 3 (ANGPTL3) regulates both plasma TG and HDL levels through inhibition of lipoprotein lipase (LPL), which hydrolyzes the triglycerides of TG-rich ...
Kelli Larissa Davie, Brandon Davies, Eric Taylor, Brian O'Neill, Miles Pufall, Madeline Shea, Marc Wold   +6 more
openaire   +1 more source

Regulation of Lipid Regulator ANGPTL8 Gene Transcript by Insulin Is Mediated by C/EBPß, and ANGPTL8 Deficiency Improves Glucose Homeostasis in Mice

Diabetes, 2018
Angiopoietin-like protein 8 (ANGPTL8) is a novel circulating protein synthesized by the liver and adipose tissue and plays a key role in regulating the plasma lipid profiles. Its expression is regulated acutely by fasting and refeeding in humans and animals.
LU ZHANG, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, LUKE NORTON   +3 more
openaire   +1 more source

The role of ANGPTL8 in metabolism and cardiovascular diseases: Consensus and controversy

Atherosclerosis
Angiopoietin-like protein 8 (ANGPTL8), a member of the angiopoietin-like protein (ANGPTL) family, is a physiological inhibitor of lipoprotein lipase (LPL), and plays a critical role in lipoprotein and triglyceride metabolism in response to nutritional cues.
Yutong Lin, Danan Wang, Duanbin Li, Fomin Zhang, Qiongjun Zhu, Xiaoyi Bao, Ning Zhang, Zakareya M. Alsalman, Shengyu Chen, Xiaolu Jiao, Wenbin Zhang   +10 more
openaire   +2 more sources