Results 131 to 140 of about 1,162 (153)

Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8

American Journal of Physiology-Endocrinology and Metabolism, 2021
Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues.
Kelli L. Sylvers-Davie, Brandon S. J. Davies   +1 more
openaire   +2 more sources

ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia

Journal of Clinical Lipidology, 2021
The role of ANGPTL3 and ANGPTL8 in lipid regulation in patients with very high levels of HDL-cholesterol and triglyceride is unknown.We examined plasma levels of ANGPTL3 and ANGPTL8 in subjects with hyperalphalipoproteinemia (HALP) and in those with severe hypertriglyceridemia (HTG).Plasma ANGPTL3 and ANGPTL8 levels were measured by ELISA in 320 ...
Chatchon Kaewkrasaesin, Waralee Chatchomchuan, Suwanna Muanpetch, Weerapan Khovidhunkit   +3 more
openaire   +2 more sources

ANGPTL8 regulates adipocytes differentiation and adipogenesis in bovine

Gene, 2019
The formation of bovine adipose tissue involves complex developmental and physiological processes that play a vital role in determining the quality of beef; however, the regulatory mechanisms are largely unknown. Angiopoietin-like protein 8 (ANGPTL8) has been reported to be involved in the development of adipose tissue; however, the mechanism of ...
Xuefeng, Wei, Shuang, Han, Shuzhe, Wang, Quizhi, Zheng, Xin, Li, Jie, Du, Jinhui, Zhao, Fei, Li, Yun, Ma   +8 more
openaire   +2 more sources

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance [PDF]

Journal of Lipid Research, 2017
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8. These effects are reversed with an ANGPTL3 blocking antibody.
Helen H Hobbs, Jesper Gromada
exaly   +4 more sources

5-OR: Adipocyte ANGPTL8 Regulates Insulin Sensitivity and Thermogenic Programing

Diabetes, 2023
ANGPTL8 (A8), expressed mainly in the liver and adipocytes, regulates lipoprotein lipase (LPL) and lipid metabolism. Hepatic A8 and ANGPTL3 form a complex that inhibits LPL. However, the precise intracellular role of A8 in adipocytes is yet to be explored.
ANINDYA GHOSH, MARC PRENTKI, YAT H. LEUNG, JEFFREY C.Y. YU, ROBERT M. SLADEK, ISABELLE CHENIER, ABEL OPPONG, MARIE-LINE PEYOT, MURTHY MADIRAJU, IRINA AL-KHAIRI, JEHAD ABUBAKER, FAHD AL-MULLA, MOHAMED ABU-FARHA   +12 more
openaire   +1 more source

Structural characterization of ANGPTL8 (betatrophin) with its interacting partner lipoprotein lipase

Computational Biology and Chemistry, 2016
Angiopoietin-like protein 8 (ANGPTL8) (also known as betatrophin) is a newly identified secretory protein with a potential role in autophagy, lipid metabolism and pancreatic beta-cell proliferation. Its structural characterization is required to enhance our current understanding of its mechanism of action which could help in identifying its receptor ...
Amnah Siddiqa, Jamil Ahmad, Amjad Ali
exaly   +3 more sources

Regulation of Lipid Regulator ANGPTL8 Gene Transcript by Insulin Is Mediated by C/EBPß, and ANGPTL8 Deficiency Improves Glucose Homeostasis in Mice

Diabetes, 2018
Angiopoietin-like protein 8 (ANGPTL8) is a novel circulating protein synthesized by the liver and adipose tissue and plays a key role in regulating the plasma lipid profiles. Its expression is regulated acutely by fasting and refeeding in humans and animals.
LU ZHANG, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, LUKE NORTON   +3 more
openaire   +1 more source

ANGPTL8 enhances insulin sensitivity by directly activating insulin-mediated AKT phosphorylation

Gene, 2020
ANGPTL8 is a 22-KDa protein in the angiopoietin-like family. It is a liver-derived hormone that dynamically regulates glucose metabolism after refeeding. The mechanism of its regulation of glucose metabolism is unclear. We analyzed the effect of ANGPTL8 overexpression on glucose tolerance in the mouse liver by tail vein hydrodynamic transfection.
Zongli, Zhang, Haiqing, Wu, Longjun, Dai, Yue, Yuan, Yanshan, Zhu, Zhipeng, Ma, Xuzhi, Ruan, Xingrong, Guo   +7 more
openaire   +2 more sources

ANGPTL8 Promotes the Ability of ANGPTL3 to Inhibit Lipoprotein Lipase

The FASEB Journal, 2017
Lipoprotein lipase (LPL) is critically important for the delivery of plasma lipoprotein–derived triglycerides to peripheral tissues. Activity of LPL is carefully regulated and misregulation of LPL can contribute to metabolic diseases including obesity, metabolic syndrome, and cardiovascular disease.
Brandon S.J. Davies, Xun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Ren Zhang   +7 more
openaire   +1 more source

Dyslipidemia and ANGPTL8 evaluation in young females with Type 1 diabetes mellitus

Endocrine
ANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM).A retrospective case-control study ...
Walaa Mohammedsaeed, Dalal Binjawhar
openaire   +2 more sources