Results 161 to 170 of about 1,431 (182)

Decreased circulating levels of ANGPTL8 in Graves’ disease patients [PDF]

Hormones, 2019
Angiopoietin-like protein 8 (ANGPTL8), a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. However, little is as yet known as to whether circulating ANGPTL8 levels are altered in thyroid dysfunction.
Mengjiao Xu, Li Zhao, Yanyan Li
exaly   +3 more sources

In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats [PDF]

Diabetologia, 2015
ANGPTL8 is a circulatory hormone secreted from liver and adipose tissue that promotes pancreatic beta cell proliferation and interferes with triacylglycerol metabolism in mice. The clinical significance of its effects on inducing beta cell proliferation is limited because it causes severe hypertriacylglycerolaemia.We employed ultrasound-targeted ...
Jiaxi Chen, Shuyuan Chen, Pintong Huang   +2 more
exaly   +3 more sources

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ANGPTL8 regulates adipocytes differentiation and adipogenesis in bovine

Gene, 2019
The formation of bovine adipose tissue involves complex developmental and physiological processes that play a vital role in determining the quality of beef; however, the regulatory mechanisms are largely unknown. Angiopoietin-like protein 8 (ANGPTL8) has been reported to be involved in the development of adipose tissue; however, the mechanism of ...
Xuefeng, Wei, Shuang, Han, Shuzhe, Wang, Quizhi, Zheng, Xin, Li, Jie, Du, Jinhui, Zhao, Fei, Li, Yun, Ma   +8 more
openaire   +2 more sources

Analysis of ANGPTL8 promoter activity and screening of related transcription factors in bovine

Gene, 2021
Analysing the molecular regulation mechanism of fat deposition in yellow cattle can provide a theoretical basis for the breeding of excellent beef cattle. ANGPTL8 (angiopoietin-like protein 8) promotes the formation of lipid droplets during adipocyte differentiation.
Xuefeng, Wei, Yunchang, Zhu, Jie, Du, Xiaojie, Ma, Xue, Zhao, Yaoyao, Ma, Shuang, Han, Yun, Ma   +7 more
openaire   +2 more sources

Regulation of Lipid Regulator ANGPTL8 Gene Transcript by Insulin Is Mediated by C/EBPß, and ANGPTL8 Deficiency Improves Glucose Homeostasis in Mice

Diabetes, 2018
Angiopoietin-like protein 8 (ANGPTL8) is a novel circulating protein synthesized by the liver and adipose tissue and plays a key role in regulating the plasma lipid profiles. Its expression is regulated acutely by fasting and refeeding in humans and animals.
LU ZHANG, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, LUKE NORTON   +3 more
openaire   +1 more source

The regulation of endothelial lipase and lipoprotein lipase by ANGPTL3 and ANGPTL8

2022
Low levels of circulating high density lipoproteins (HDL) and high levels of plasma triglycerides (TG) are risk factors for cardiac disease and atherosclerosis. The liver-expressed protein angiopoietin-like 3 (ANGPTL3) regulates both plasma TG and HDL levels through inhibition of lipoprotein lipase (LPL), which hydrolyzes the triglycerides of TG-rich ...
Kelli Larissa Davie, Brandon Davies, Eric Taylor, Brian O'Neill, Miles Pufall, Madeline Shea, Marc Wold   +6 more
openaire   +1 more source

5-OR: Adipocyte ANGPTL8 Regulates Insulin Sensitivity and Thermogenic Programing

Diabetes, 2023
ANGPTL8 (A8), expressed mainly in the liver and adipocytes, regulates lipoprotein lipase (LPL) and lipid metabolism. Hepatic A8 and ANGPTL3 form a complex that inhibits LPL. However, the precise intracellular role of A8 in adipocytes is yet to be explored.
ANINDYA GHOSH, MARC PRENTKI, YAT H. LEUNG, JEFFREY C.Y. YU, ROBERT M. SLADEK, ISABELLE CHENIER, ABEL OPPONG, MARIE-LINE PEYOT, MURTHY MADIRAJU, IRINA AL-KHAIRI, JEHAD ABUBAKER, FAHD AL-MULLA, MOHAMED ABU-FARHA   +12 more
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The role of ANGPTL8 in metabolism and cardiovascular diseases: Consensus and controversy

Atherosclerosis
Angiopoietin-like protein 8 (ANGPTL8), a member of the angiopoietin-like protein (ANGPTL) family, is a physiological inhibitor of lipoprotein lipase (LPL), and plays a critical role in lipoprotein and triglyceride metabolism in response to nutritional cues.
Yutong Lin, Danan Wang, Duanbin Li, Fomin Zhang, Qiongjun Zhu, Xiaoyi Bao, Ning Zhang, Zakareya M. Alsalman, Shengyu Chen, Xiaolu Jiao, Wenbin Zhang   +10 more
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ANGPTL8 Promotes the Ability of ANGPTL3 to Inhibit Lipoprotein Lipase

The FASEB Journal, 2017
Lipoprotein lipase (LPL) is critically important for the delivery of plasma lipoprotein–derived triglycerides to peripheral tissues. Activity of LPL is carefully regulated and misregulation of LPL can contribute to metabolic diseases including obesity, metabolic syndrome, and cardiovascular disease.
Brandon S.J. Davies, Xun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Ren Zhang   +7 more
openaire   +1 more source

Dyslipidemia and ANGPTL8 evaluation in young females with Type 1 diabetes mellitus

Endocrine
ANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM).A retrospective case-control study ...
Walaa Mohammedsaeed, Dalal Binjawhar
openaire   +2 more sources