Results 141 to 150 of about 45,951 (270)

The specific mediating role of social anhedonia in the relationship between childhood emotional abuse and depressive symptoms in bipolar disorder

BMC Psychiatry
Background Childhood trauma is a well-established risk factor for greater severity and poorer prognosis of bipolar depression. While anhedonia particularly in the social domain is theorized to link early adversity to depressive symptoms, this specific ...
Peiyun Zhang, Qianqian Qin, Kaihong Tang, Weihong Jiang, Chao Liu, Qi Yan   +5 more
doaj   +1 more source

Relations among daily symptoms of depression

British Journal of Psychology, Volume 117, Issue 4, Page 1432-1448, November 2026.
Abstract Research has often treated depression as a unitary construct, relying on severity scores or diagnostic thresholds; however, recent studies emphasize that depression is a heterogeneous disorder characterized by dynamic symptom interactions. We aimed to identify unique relations among depressive symptoms when examined longitudinally.
Meghan E. Quinn, Mary E. Kleinman, John P. Standring, Qimin Liu   +3 more
wiley   +1 more source

Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Clinical, Cosmetic and Investigational Dermatology
Marta Szepietowska, Aleksandra A Stefaniak, Piotr K Krajewski, Łukasz Matusiak Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Piotr K Krajewski, Department of Dermatology ...
Szepietowska M, Stefaniak AA, Krajewski PK, Matusiak Ł   +3 more
doaj  

Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment

British Journal of Pharmacology, Volume 183, Issue 21, Page 6291-6305, November 2026.
Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core pathophysiological framework of major depressive disorder, one of the leading causes of disability worldwide. Chronic stress is a major
Paola Brivio, Arianna Palumbo, Maria Teresa Gallo, Filippo Umberto Tancredi Veronesi, Giorgia Cortinovis, Piotr Gruca, Magdalena Lason, Ewa Litwa, Dominika Biala, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese   +11 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Anhedonia [PDF]

, 2020
openaire   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 7, Page 431-440, October 2026.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

Diagnosis of an Arachnoid Cyst in a Patient Presenting With Uncommon Depressive Symptoms: Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Arachnoid cysts are most commonly asymptomatic and usually do not need any active treatment. Currently, psychiatric symptoms are seldom taken into consideration during treatment evaluations in this patient population. We present this case of a young man who was treated in our hospital for signs of depression.
Ruth Arias‐Hidalgo, Felipe Ortuño, Sergio Manuel Solís‐Barquero, Maria Fernández‐Seara, Reyes García de Eulate, Aziz Yarkin   +5 more
wiley   +1 more source

Compound Ciwujia Granules Attenuate Stress‐Induced Anxiety‐ and Depression‐Like Behaviors via Inhibition of TNF‐α‐Associated Neuroinflammation in the dmPFC

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
By restoring glutamatergic neuronal activity, suppressing TNF‐related inflammatory signaling pathway, and reducing microglial overactivation in the dmPFC, CWJ ameliorated stress‐induced behavioral abnormalities. ABSTRACT Aims Compound Ciwujia Granules (CWJ) have shown antidepressant‐like effects, but the neural and molecular mechanisms underlying these
Fei Tian, Yi Li, Mengyu Dai, Yihan Guo, Bingbing Liao, Yingdan Zhang, Xin Gong, Lanying Liu, Dongdong Shi, Zhen Wang   +9 more
wiley   +1 more source

Agomelatine as augmentation therapy with second‐generation antipsychotics for negative symptoms of schizophrenia: An open‐label randomised clinical trial and electroencephalogram‐derived model for treatment response prediction

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Negative symptoms are a core diagnostic domain of schizophrenia that affect functional outcomes and remain difficult to treat. Agomelatine, a novel antidepressant with melatonin receptor agonism and serotonin 2C receptor antagonism, may have therapeutic potential.
Wanyan Zhou, Fei Liang, Nizhe Chen, Yao Zhang, Xiaoxiao Wang, Xin Li, Daofeng Lu, Fang Guo, Yuan Yao, Jiayu Zhu, Chengjia Shen, Chongze Wang, Peiyun Zhang, Lilan Zhao, Ying Wang, Jinyu Han, Wei Li, Haisu Wu, Peijuan Wang, Qi Yan, Ping Zhang, Qinyu Lv, Zhenghui Yi   +22 more
wiley   +1 more source