Results 151 to 160 of about 7,998 (258)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Anhedonia [PDF]

, 2020
openaire   +1 more source

Anhedonia in Major Depressive Disorder: Prevalence and Treatment Expectations and Satisfaction with Treatment Goals Among Patients and Physicians in Asia-Pacific

Keira Herr,1 Michael Berk,2 Wei-Lieh Huang,3 Tadafumi Kato,4 Jung Goo Lee,5,6 Chong Guan Ng,7 Zhen Wang,8 Thomas David Webb,1 Mami Kasahara-Kiritani,9 Lawrence Phillip Vandervoort10 1Janssen Asia Pacific, Singapore; 2School of Medicine, Deakin University,
Ng CG, Vandervoort LP, Herr K, Huang WL, Webb TD, Lee JG, Berk M, Kato T, Wang Z, Kasahara-Kiritani M   +9 more
core  

Exploring Group Differences in Attenuated Symptoms and Functioning Between Clinical High‐Risk Individuals With and Without Posttraumatic Stress Disorder

Early Intervention in Psychiatry, Volume 20, Issue 7, July 2026.
ABSTRACT Background Posttraumatic stress disorder (PTSD) is a common comorbid diagnosis in psychotic disorders. However, little is known about the effect of comorbid PTSD in youth at clinical high risk (CHR) for psychosis. Purpose The purpose of this study was to investigate group differences in symptom severity, risk for psychotic conversion and ...
Danielle Pham, Leda Kennedy, Jean Addington, Carrie E. Bearden, Tyrone D. Cannon, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Diana O. Perkins, William Stone, Elaine F. Walker, Scott W. Woods, Kristin S. Cadenhead   +12 more
wiley   +1 more source

Analyzing transdiagnostic internalizing symptoms in a global sample of trauma‐exposed children using pooled individual participant data: a latent transition analysis

Journal of Child Psychology and Psychiatry, Volume 67, Issue 7, Page 1159-1175, July 2026.
Background Children often experience both posttraumatic stress (PTS) and depression after potentially traumatic events (PTEs). Latent class analyses (LCAs) identify subgroups with different co‐occurring symptoms, but little is known about what predicts transitions between these symptom classes over time. Analyzing these transitions could reveal factors
Yaara Sadeh, Leila Graham, Marthe R. Egberts, Lonneke I.M. Lenferink, Nancy Kassam‐Adams   +4 more
wiley   +1 more source

Uncovering Frailty in Burning Mouth Syndrome: Insights From a SUNFRAIL+ Based Multidimensional Assessment

Journal of Oral Rehabilitation, Volume 53, Issue 7, Page 1347-1362, July 2026.
Burning Mouth Syndrome patients showed a markedly higher frailty alert rate than controls using the SUNFRAIL+ multidimensional screening tool, with increased polypharmacy, cognitive decline, reduced mobility and depressive symptoms. These findings suggest that BMS is associated with a broader frailty profile requiring integrated physical, cognitive and
Federica Canfora, Giulia Ottaviani, Antonietta Argiuolo, Alessandra Giorgiutti, Guido Iaccarino, Katia Rupel, Sabina Saccomanno, Vincenzo De Luca, Michele Virgolesi, Elizabeth Moloney, Rónán O'Caoimh, Giuseppe Liotta, Michele Davide Mignogna, Maddalena Illario, Daniela Adamo   +14 more
wiley   +1 more source

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

The influence of anhedonia on feedback negativity in major depressive disorder

, 2014
Anhedonia is associated with reward-processing deficits of the dopamine system, which may increase the risk of depression. Nevertheless, few previous studies have examined the influence of hedonic tone on event-related potential (ERP) measures of reward ...
Wang, Ling-zhi, Chan, Raymond C. K., Liu, Wen-hua, Shen, Yue, Cheung, Eric F. C., Li, Zhi, Shang, He-rui   +6 more
core  

Human–Artificial Intelligence Relationships in Lacanian Perspective: Desire, Silence, and the Big Other

International Journal of Applied Psychoanalytic Studies, Volume 23, Issue 2, June 2026.
ABSTRACT This article offers a Lacanian psychoanalytic interpretation of emerging forms of human–artificial intelligence (AI) relationships, particularly emotionally responsive systems such as AI companions and AI girlfriends. It addresses the notion of “AI psychosis,” understood not as a diagnostic category but as a descriptive term for disturbances ...
Tibor A. Brečka
wiley   +1 more source