Results 161 to 170 of about 45,951 (270)

Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication‐Free Patients With Major Depressive Disorder: An Exploratory Study

PsyCh Journal, Volume 15, Issue 5, October 2026.
ABSTRACT Disrupted‐in‐Schizophrenia 1 (DISC1) has been implicated in major psychiatric disorders, but the relationship between circulating DISC1 protein and dimensional motivation and pleasure‐related features in major depressive disorder (MDD) is unknown.
Zhenhua Zhu, Xuyuan Yin, Jia Huang, Yi Wang, Qi Qi, Peijie Wang, Simon S. Y. Lui, Li Hui, Raymond C. K. Chan   +8 more
wiley   +1 more source

Reward-related functioning across diabetes subtypes: associations with glycaemic control. [PDF]

Front Endocrinol (Lausanne)
Kurtulmuş A, Parlakkaya Yıldız FB, Sahinbaş EE, Özyıldırım M, Ertunç P, Çelik Z, Takır M.   +6 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Research agenda to advance anhedonia assessment, understanding and treatment: an ECNP-GALENOS expert meeting report. [PDF]

BMJ Ment Health
Penninx BWJH, Kas MJH, Dawson GR, Correll CU, Harmer CJ, Buhl DL, De Prisco M, Downs J, Hernaus D, Hopkins SC, Husain M, Johnson S, Mckernan R, Ostinelli EG, Pizzagalli DA, Pryce CR, Reif A, Schreiber R, Serretti A, Siafis S, Tunbridge E, Umbricht D, Vinkers CH, Cipriani A.   +23 more
europepmc   +1 more source

Thriving in the City: An Urban Living Lab to Facilitate Recovery From Psychosis

Early Intervention in Psychiatry, Volume 20, Issue 10, October 2026.
ABSTRACT Aim Protective factors and resources to recovery in urban milieus remain poorly understood, calling for user‐led initiatives to develop relevant interventions embedded in patients' daily‐life environments. Experience‐based co‐design is key to need‐based interventions in real‐life settings and calls for novel methodologies.
Lilith Abrahamyan Empson, Philippe Conus, Ola Söderström, Marc Winz, Sandra Vieira, Jérôme Favrod, Aurora Ruggeri, Jules Brischoux, Anastasie Jordan, Philippe Golay   +9 more
wiley   +1 more source

Alignment of natural language processing-derived RDoC scores with depression, anhedonia, and anxiety in psychiatric electronic health records. [PDF]

NPP Digit Psychiatry Neurosci
Kuhn M, Ahn S, Holstein V, Rossvall A, Layfield S, Duffy LA, Wong S, Ellis R, Gelwan E, Rodriguez-Villa F, Yip A, Vahia I, Pizzagalli DA, Ressler KJ, Vogelgsang J.   +14 more
europepmc   +1 more source

Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review

Early Intervention in Psychiatry, Volume 20, Issue 10, October 2026.
ABSTRACT Introduction Psychiatric biomarker research has traditionally been organized around diagnostic categories, but clinical heterogeneity, comorbidity and shared biological mechanisms across psychiatric conditions have increased interest in transdiagnostic approaches.
Katelyn Hummel, Luigi Boccuto, Sara M. Sarasua, Kendra Allison, Garrie B. Thompson III   +4 more
wiley   +1 more source

Psychoeducation for Youth at Clinical High‐Risk of Psychosis

Early Intervention in Psychiatry, Volume 20, Issue 10, October 2026.
ABSTRACT Introduction Psychoeducation may be a useful first‐step intervention for youth at clinical high risk of developing psychosis (CHR). The aim of this study was to describe clinical improvement after receiving psychoeducation and adherence to the treatment.
Jean Addington, Lu Liu, Cari Jahraus, Erin Jones, Joyce Singh   +4 more
wiley   +1 more source

Anhedonia in Major Depressive Disorder: Prevalence and Treatment Expectations and Satisfaction with Treatment Goals Among Patients and Physicians in Asia-Pacific

Keira Herr,1 Michael Berk,2 Wei-Lieh Huang,3 Tadafumi Kato,4 Jung Goo Lee,5,6 Chong Guan Ng,7 Zhen Wang,8 Thomas David Webb,1 Mami Kasahara-Kiritani,9 Lawrence Phillip Vandervoort10 1Janssen Asia Pacific, Singapore; 2School of Medicine, Deakin University,
Ng CG, Vandervoort LP, Herr K, Huang WL, Webb TD, Lee JG, Berk M, Kato T, Wang Z, Kasahara-Kiritani M   +9 more
core  

Effects of Serotonin Transporter Genotype and (Un)Predictable Maternal Separation on Affective, Cognitive, and Social Behaviors in Female Rats

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
Female rats of three serotonin transporter (SERT) genotypes were exposed to maternal separation paradigms modeling early life stress, followed by adult behavioral testing. Maternal separation did not consistently induce depression‐related behavioral phenotypes in SERT‐deficient females.
Danielle J. Houwing, Mayerli A. Prado‐Rivera, Jenny Borkent, Marrit Gerbrandy, Chantal Arling, Jocelien D. A. Olivier   +5 more
wiley   +1 more source