Results 171 to 180 of about 7,998 (258)

Anhedonia

The Iowa Review, 1992
openaire   +1 more source

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

Restoration of Excitation‐Inhibition Balance and Improvement of Schizophrenia‐like Behavioral Deficits via Electroacupuncture

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Ablation of nNos from Erbb4‐positive neurons induces impaired GABAergic transmission and disruption of excitatory and inhibitory balance, which further cause hyperactivity of pyramidal neurons, resulting in schizophrenia‐relevant behavioral deficits. EA treatment rescues decreased GABAergic transmission and restores excitatory and inhibitory balance by
Chaofan Wan, Yucen Xia, Jinglan Yan, Weipeng Lin, Yuanjia Zheng, Yiqiu Lin, Lin Yao, Yongjun Chen   +7 more
wiley   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

Anhedonia in flux: Understanding the associations of emotion regulation and anxiety with anhedonia variability

Prior work has indicated that depressive symptoms are relatively unstable given that they can vary dramatically across time, including within hours (Nemesure et al., 2024).
E. Samuel Winer, Nicholas C. Jacobson, Michael R. Gallagher, Damien Lekkas, Amanda C Collins   +4 more
core  

Evaluation of Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kappa‐B Ligand (RANKL) Biomarker Concentrations in the Saliva of Patients with Periodontitis and Depression

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Background and Objectives Periodontitis is a chronic inflammatory disease affecting tooth‐supporting structures, while depression is a common mental disorder with emotional and behavioral disturbances. Previous studies suggest a potential association between the two conditions.
Azadeh Esmaeilnejad, Ardeshir Lafzi, Seyedeh Morvarid Neishabouri, Mohammad Mohsen Bigham   +3 more
wiley   +1 more source

Investigation of Anhedonia: A Literature Review

Investigation of Anhedonia serves as an independent study where a Literature Review was conducted to research different aspects and elements of the psychological phenomenon known as Anhedonia.
Littlejohn, Austin G
core  

Differential Responsiveness to Exercise and Cognitive Remediation in Physical Health in People With Schizophrenia: Results From the CORTEX‐SP Study

European Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT Non‐pharmacological interventions, such as exercise and cognitive remediation, have been widely investigated in people with schizophrenia (SZ), showing beneficial effects and supporting their role as complementary approaches to pharmacological treatment.
Mikel Tous‐Espelosin, Nagore Iriarte‐Yoller, Agurne Sampedro, Iker Lasa‐Sagaseta, Cristóbal Pavon, Natalia Ojeda, Pedro Sanchez, Javier Peña, Sara Maldonado‐Martín   +8 more
wiley   +1 more source

KREO Prevents CUMS‐Induced Depressive‐Like Behavior via Modulation of the BDNF Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study showed that Chinese Kushui Rose Essential Oil (KREO) can alleviate depressive symptoms, increase voluntary activity, and enhance exploratory behavior in mice induced with chronic unpredictable mild stress (CUMS) by elevating serotonin (5‐HT) levels and reducing hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis.
Yanni Wang, Zhaorong Yue, Manjie Xu, Wenjun Xu, Weizhong Zhang, Xiaolong Li, Qinghong Liu, Kailong Guan, Zewen Zhang, Yang Li, Xin Wang, Hongyu Li   +11 more
wiley   +1 more source

Anhedonia

, 2016
openaire   +2 more sources