Results 171 to 180 of about 45,951 (270)

The Role of Kappa‐Opioid Receptor/Dynorphin System in Modulating Neural‐Circuits of Depression and Anxiety—A Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Major depression and anxiety disorders are psychiatric disorders that involve a great number of people. There is a growing need for new and better pharmacological treatments for these diseases. Kappa‐opioid receptor (KOR) antagonists seem to be a promising new pathway for the development of new antidepressants and anxiolytics, but a great ...
Cristian Ciotei, Horia Păunescu, Cristina Lungu, Adriana‐Alexandra Marica, Mihai Florin Tănase, Ruxandra‐Cristina Marin, Mihnea Costescu, Ion Fulga, Oana Andreia Coman   +8 more
wiley   +1 more source

Altered core depressive symptom balance in post-COVID fatigue: reduced depressed mood in an exploratory matched historical-control study. [PDF]

Front Psychiatry
Tusconi M, Fornaro M, Atzeni M, Cantone E, Pintus E, Primavera D, Nardi AE, Carta MG.   +7 more
europepmc   +1 more source

Within‐person longitudinal associations between depressive symptoms and interpersonal problems in adolescent girls

Journal of Child Psychology and Psychiatry, Volume 67, Issue 10, Page 1701-1713, October 2026.
Background Adolescence, particularly for girls, is a period of heightened risk for depressive symptoms and increased interpersonal stress. Although depressive symptoms and interpersonal problems are known to co‐occur, prior work has predominantly examined between‐person associations, leaving within‐person processes unclear.
Leehyun Yoon, Kelsey E. Magee, Stephanie D. Stepp, Erika E. Forbes, Kate E. Keenan, Alison E. Hipwell, Amanda E. Guyer   +6 more
wiley   +1 more source

Psychological vulnerability and opioid medication use disorder risk in chronic pain: the mediating role of affective states and gender differences. [PDF]

Front Public Health
Lorente JD, Molins F, Padilla F, Serrano-Herrera D, Monsalve Dolz V, Mínguez A, De Andres J, Serrano MÁ, Hipólito L.   +8 more
europepmc   +1 more source

Emotional Blunting During Antidepressant Treatment: Implications for Clinical Decision‐Making and Patient‐Centred Care

Journal of Evaluation in Clinical Practice, Volume 32, Issue 7, October 2026.
ABSTRACT Rationale Emotional blunting is frequently reported during antidepressant treatment but remains conceptually underdefined. Reduced emotional reactivity and affective intensity may represent therapeutic benefit, an adverse effect, residual depressive symptomatology, or a context‐dependent combination of these possibilities.
Carlos De las Cuevas
wiley   +1 more source

Olfactory Training and Depressive Symptoms in Older Adults: A Randomized Placebo‐Controlled Trial With Exploratory Evidence in Moderate Depression

Journal of Sensory Studies, Volume 41, Issue 5, October 2026.
ABSTRACT The risk of developing depressive symptoms increases with age. The following study aimed to verify if olfactory training may relieve symptoms of depression in the older population. Older participants (N = 101, Mage = 72.6, SD = 5.44, 88% women) participated in this study.
Barbara Żyżelewicz, Michał Pieniak, Aleksandra Reichert, Marta Rokosz, Daniel Marek, Anna Oleszkiewicz   +5 more
wiley   +1 more source

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson, Mats Lekander, Camilla I. Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J. T. Balter   +6 more
wiley   +1 more source

Loss of pleasure (Anhedonia): A sex-dependent, cross-species consequence of unpredictable signals to the perinatal brain. [PDF]

Neurobiol Stress
Zhou AM, Tetzlaff MR, Glynn LM, Sandman CA, Stern HS, Baram TZ, Davis EP.   +6 more
europepmc   +1 more source

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

Higher Lipopolysaccharide Levels Are Linked to Less Anhedonia and Lower Severity of Major Depressive Disorder. [PDF]

Brain Sci
Milasauskiene E, Burkauskas J, Jesmanas S, Gleizniene R, Borutaite V, Raskauskiene N, Skemiene K, Adomaitiene V, Gradauskiene B, Brown GC, Steibliene V.   +10 more
europepmc   +1 more source