Results 41 to 50 of about 45,951 (270)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia

Frontiers in Psychiatry, 2021
Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure.
Lingfang Yu, Hua Ni, Zenan Wu, Xinyu Fang, Yan Chen, Dandan Wang, Chen Zhang   +6 more
doaj   +1 more source

Social Anhedonia, Loneliness and Faces

, 2021
Data: The data contains the Revised Social Anhedonia Scale, UCLA Loneliness Scale and the upright faces with different emotions % accuracy correct from the Palmero database of expressions.
Barkus, E (via Mendeley Data)
core   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Anhedonia and Depressive Disorders

Clinical Psychopharmacology and Neuroscience, 2023
Anhedonia is a core symptom of depression and of several psychiatric disorders. Anhedonia has however expanded from its original definition to encompass a spectrum of reward processing deficits that received much interest in the last decades. It is a relevant risk factor for possible suicidal behaviors, and that it may operate as an independent risk ...
openaire   +2 more sources

Effects of olanzapine on anhedonia in schizophrenia: mediated by complement factor H

Frontiers in Psychiatry, 2023
BackgroundAnhedonia is a trans-diagnostic symptom in schizophrenia and MDD. Our recent work indicated that increased plasma level of complement factor H (CFH) is associated with anhedonia in major depressive disorder.
Yi Zhang, Wei Tang, Weiping Wang, Feikang Xu, Weihong Lu, Chen Zhang, Chen Zhang   +6 more
doaj   +1 more source

A three-year longitudinal study of social anhedonia and comparison groups [PDF]

, 2005
" The present study is a three-year longitudinal reassessment of schizotypic young adults and comparison participants identified by the Revised Social Anhedonia Scale (Eckblad, Chapman, Chapman, & Mishlove, 1982).
Diaz, Martha Ann, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Motivation deficits in individuals with social anhedonia

, 2018
Patients with schizophrenia have been reported to exhibit anhedonia, a reduced hedonic capacity and deficits in motivation for reward pursuit. However, it is unclear whether these deficits also exist in at-risk individuals prone to psychosis or not.
Yue, Xiao dong, Jiao Wang, Chan, Raymond C. K., Chan, RCK, Cheung, EFC, Wang, Jiao, Jia Huang, Raymond C.K. Chan, Chan, Raymond C.K., Cheung, Eric F.C., J. Huang, Huang, Jia, Wang, J, Xiao-dong Yue, Yue, Xiao-dong, Cheung, Eric F. C., Huang, J, Simon S.Y. Lui, Yue, XD, Lui, Simon S. Y., Lui, SSY, Lui, Simon S.Y., Eric F.C. Cheung   +22 more
core   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Anhedonia: A Concept Analysis [PDF]

Archives of Psychiatric Nursing, 2013
Anhedonia presents itself in a myriad of disease processes. To further develop our understanding of anhedonia and effective ways to manage it, the concept requires clear boundaries. This paper critically examined the current scientific literature and conducted a concept analysis of anhedonia to provide a more accurate and lucid understanding of the ...
Nancy, Ho, Marilyn, Sommers
openaire   +2 more sources