Results 61 to 70 of about 7,998 (258)

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders [PDF]

Consortium Psychiatricum
BACKGROUND: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has a transdiagnostic nature and is one of the key symptoms of mood disorders, schizophrenia, addictions, and somatic ...
Evgeny Kasyanov, Darya Pinakhina, Aleksandr Rakitko, Ekaterina Vergasova, Danat Yermakovich, Grigoriy Rukavishnikov, Larisa Malyshko, Yaroslav Popov, Elena Kovalenko, Anna Ilinskaya, Anna Kim, Nikolay Plotnikov, Nikolay Neznanov, Valeriy Ilinsky, Aleksandr Kibitov, Galina Mazo   +15 more
doaj   +1 more source

The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia [PDF]

, 2016
Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy.
Li, Xu, Zeng, Ya-wei, Chan, Raymond C. K., Shi, Hai Song, Xie, Wen Lan, Leung, Ada W.S., Li, Ke, Li, Zhi, Yang, Zhuo Ya, Chan, Raymond C.K., Cheung, Eric F.C., Leung, Ada W. S., Shi, Hai-song, Cheung, Eric F. C., Xie, Wen-lan, Yang, Zhuo-ya, Zeng, Ya Wei, Lui, Simon S. Y., Lui, Simon S.Y.   +18 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Social Anhedonia, Loneliness and Face Affect Recognition

, 2020
Background: Loneliness (a subjective sense of disconnection with others) and social anhedonia (reduced pleasure from social environments and interactions) involve disruptions of, and pleasure from, social connection.
Barkus, E (via Mendeley Data)
core   +2 more sources

When effort pays off: An experimental investigation into action orientation and anxiety as buffering factors between anhedonia and reward motivation.

PLoS ONE
Reward motivation, a construct tied to depression, has been studied using the Effort-Expenditure for Rewards Task (EEfRT). Prior work indicates that anhedonia can reduce reward motivation on the EEfRT, as those with higher levels of anhedonia tend to ...
Michael R Gallagher, Amanda C Collins, Samantha L Anduze, E Samuel Winer   +3 more
doaj   +1 more source

White matter microstructural abnormalities and their association with anticipatory anhedonia in depression

, 2017
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood.
Tian, Kai, Kai Tian, Yang, Xin-hua, Chan, Raymond C. K., Xin-hua Yang, Dong-fang Wang, Raymond C.K. Chan, Wang, Dong-fang, Yi Wang, Wang, Yi, Xie, Guang-rong, Cheung, Eric F. C., Guang-rong Xie, Eric F.C. Cheung   +13 more
core   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Post‐COVID‐19 fatigue and anhedonia: A cross‐sectional study and their correlation to post‐recovery period

Neuropsychopharmacology Reports, 2021
Background Individuals infected by the novel coronavirus (SARS‐CoV‐2) have experienced different psychiatric manifestations during the period of infectivity and post‐COVID‐19 infection.
Samir El Sayed, Doaa Shokry, Sarah Mohamed Gomaa   +2 more
doaj   +1 more source