Results 61 to 70 of about 45,951 (270)
Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition
Epilepsia, EarlyView.Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga +5 more
wiley +1 more source
Happy or not? An investigative study on well-being and anhedonia in everyday life.
PLoS ONEAnhedonia, the inability to experience pleasure or interest in activities, is a key symptom across various psychiatric disorders, including depression. It links to poor quality of life, higher suicide risk, and poorer prognosis.
Sarah A Merklein +2 more
doaj +1 more source
Suicidal ideations among medical students: The role of anhedonia and type D personality.
PLoS ONE, 2019 BackgroundThe relationships between hedonic deficits, type D personality and suicidal ideation were explored in a group of medical students.MethodsIn a cross-sectional study, 382 medical students filled out several questionnaires measuring suicide risk ...
Gwenolé Loas +3 more
doaj +1 more source
Wanting and liking: the effects of depressive symptoms and anhedonia on hedonic responses to a laboratory task and in everyday life [PDF]
, 2019 Few studies have examined the presence or impact of anhedonia in the hedonic experiences of daily life in people with depression, with the majority of studies on anhedonia and depression being single time-point questionnaire studies or laboratory-based ...
Maloney, Kathleen H. +1 more
core
The effect of physical activity on anhedonia in individuals with depressive symptoms
, 2021 The therapeutic effect of antidepressants has been demonstrated for anhedonia in patients with depression. However, antidepressants may cause side-effects, such as cardiovascular dysfunction.
Shum, David H. K. +17 more
core +1 more source
Exploration, EarlyView.Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li +23 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective This study examined the psychometric properties of the Edinburgh Postpartum Depression scale (EPDS) in a large‐scale community‐based perinatal sample in the Philippines. Methods This study involved a total of 1025 pregnant women (n = 356), postpartum women (n = 500), and women who experienced stillbirth or neonatal death (n = 169 ...
Arbie Diane Flores‐Davantes +13 more
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Attentional control mediates the relationship between social anhedonia and social impairment
Frontiers in Psychology, 2014 Social anhedonia, a traitlike disinterest in social contact and diminished capacity to experience pleasure from social interactions, is consistently associated with social impairments in both healthy and clinical populations.
Laura Magdalen Tully +2 more
doaj +1 more source
Prospective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms
European Journal of Psychotraumatology, 2022 Background Anhedonia, the reduction of pleasure and reward-seeking behaviour, is a transdiagnostic symptom with well-described neural circuit mediators.
Dean T. Acheson +6 more
doaj +1 more source