Results 51 to 60 of about 45,951 (270)

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Emotional Responses (Intensity/Valence) Fulfill RDoC Criteria but Remain Excluded From Diagnostic Classifications of Mood Disorders. [PDF]

Bipolar Disord
ABSTRACT Objectives Categorical classifications of depression, such as DSM‐5 and ICD, are limited by high clinical heterogeneity, arbitrary diagnostic thresholds, and weak links to underlying pathophysiology. In line with the Research Domain Criteria (RDoC) framework, this article proposes a dimensional and mechanistic approach centered on emotional ...
Henry C, Müh C, de Badts CH, Alonso M, Berkovitch L.   +4 more
europepmc   +2 more sources

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Altered corticostriatal functional connectivity in individuals with high social anhedonia

, 2016
Background. Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. Social anhedonia has been identified as a predictor for the development of schizophrenia spectrum disorders.
Liu, W. -H., Zou, L. -Q., Li, Z., Wei, X. H., Geng, F. L., Pantelis, C., Jiang, X. Q., Liu, W. H., Jiang, X. -Q., Wei, X. -H., Chan, R. C.K., Lui, S. S.Y., Lui, S. S. Y., Wang, Y., Cheung, E. F.C., Cheung, E. F. C., Chan, R. C. K., Geng, F. -L., Zou, L. Q.   +18 more
core   +1 more source

Developmental Trajectories of Anhedonia in Preclinical Models [PDF]

, 2022
This chapter discusses how the complex concept of anhedonia can be operationalized and studied in preclinical models. It provides information about the development of anhedonia in the context of early-life adversity, and the power of preclinical models ...
Birnie, Matthew T, Stephen V. Mahler, Tallie Z. Baram, Mahler, Stephen V, Sophia C. Levis, Levis, Sophia C, Baram, Tallie Z, Matthew T. Birnie   +7 more
core   +1 more source

Examining Behavioral Markers of Reward Processing Dysfunction in Individuals With Anorexia Nervosa and Suicidal Thoughts and Behaviors

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Suicidal thoughts and behaviors (STBs) are common in individuals with anorexia nervosa (AN), including those who are weight‐restored. Dysfunction in reward processing has been proposed as a mechanism linking AN to STBs; however, little research has interrogated putative reward links between these phenomena. The present study examined
Soo‐Eun Lee, Olivia Chapman, Serena J. Gu, Karly Derrigo, Scott J. Crow, Ann F. Haynos   +5 more
wiley   +1 more source

Anhedonia and 24-hour movement behaviours in adulthood

Journal of Affective Disorders Reports
Introduction: This study aimed to examine the association between self-reported physical and social anhedonia in young adulthood with the composition of movement behaviours in a 24-h cycle, including physical activity, sedentary behaviour, and sleep ...
Anna-Kaisa Karppanen, Jouko Miettunen, Tuula Hurtig, Anna-Maiju Leinonen, Raija Korpelainen, Vahid Farrahi   +5 more
doaj   +1 more source

Decrease of vanillin sucrose intake by victorious and defeated mice: development of anhedonia? [PDF]

, 2007
Hedonic reactions to various rewards play a key role in various forms of motivated behavior. The influence of repeated experience of social victories or defeats in daily agonistic interactions between male mice on voluntary consumption of vanillin ...
Damira F. Avgustinovich, Irina L. Kovalenko, Natalia N. Kudryavtseva, Natalia P. Bondar   +3 more
core