Results 71 to 80 of about 7,998 (258)

Anhedonia and Depressive Disorders

Clinical Psychopharmacology and Neuroscience, 2023
Anhedonia is a core symptom of depression and of several psychiatric disorders. Anhedonia has however expanded from its original definition to encompass a spectrum of reward processing deficits that received much interest in the last decades. It is a relevant risk factor for possible suicidal behaviors, and that it may operate as an independent risk ...
openaire   +2 more sources

Reward Processing in Binge Eating and Harmful Drinking: A Systematic Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge eating and harmful drinking commonly co‐occur, which worsens the physical and psychological consequences associated with either behavior alone. Reward processing alterations have been demonstrated among individuals who engage in binge eating or harmful drinking alone; however, there is limited understanding of how different ...
Taylor N. Breddy, Kendall M. Schmidt, Lindsay P. Bodell   +2 more
wiley   +1 more source

Anhedonia in the shadow of chronic social defeat stress, or When the experimental context matters

, 2008
One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events,
Dmitry A. Smagin, Damira F. Avgustinovich, Irina L. Kovalenko, Natalia N. Kudryavtseva, Natalia P. Bondar   +4 more
core  

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Affective processing in anhedonia: An ERP study [PDF]

openBackground: Anhedonia, defined as a loss of pleasure towards appetitive stimuli, is a core symptom of depression and a vulnerability factor for its development.
MEJZA, ROZA
core  

Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

, 2019
Previous studies have suggested that the degree of social anhedonia reflects the vulnerability for developing schizophrenia. However, only few studies have investigated how functional network changes are related to social anhedonia.
Hinrich, Jesper L, Chan, Raymond C K, Hinrich, Jesper Løve, Chan, Raymond C. K., Madsen, Kristoffer H., Krohne, Lærke Gebser, Moerup, Morten, Mørup, Morten, Hinrich, Jesper L., Wang, Yi, Yi Wang, Madsen, Kristoffer H, Krohne, Laerke Gebser, Jesper L. Hinrich, Madsen, Kristoffer Hougaard, Chan, Raymond CK, Morten Moerup, Laerke Gebser Krohne, Raymond C. K. Chan, Kristoffer H. Madsen   +19 more
core   +1 more source

Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the occurrence, clinical correlates, and screening accuracy of depressive symptoms (DS) among adults with epilepsy in Georgia, a country with limited mental health resources. Methods We conducted a cross‐sectional study in adults with epilepsy attending a tertiary care center. We assessed DS using two validated tools: the
Ketevan Silagadze, Eka Burkadze, Maka Areshidze, Teimuraz Silagadze, Sofia Kasradze, Josemir W. Sander   +5 more
wiley   +1 more source

Conceptualizing anhedonias and implications for depression treatments

Psychology Research and Behavior Management, 2019
E Samuel Winer, D Gage Jordan, Amanda C Collins Department of Psychology, Mississippi State University, Starkville, MS 39762, USA Abstract: Anhedonia has been implicated as a core symptom of depression and schizophrenia, and studying anhedonia has ...
Winer ES, Jordan DG, Collins AC
doaj  

The effects of working memory training on enhancing hedonic processing to affective rewards in individuals with high social anhedonia

, 2016
Anhedonia is a core feature of the negative symptoms of schizophrenia and is less responsive to anti psychotic medication. Little is known whether anhedonia could be alleviated by cognitive training.
Li, Xu, Chan, Raymond C. K., Shi, Hai Song, Zou, Lai Quan, Xiao, Ya Hui, Yang, Zhuo Ya, Chan, Raymond C.K., Li, Huan-Huan, Cheung, Eric F.C., Xiao, Ya-Hui, R.C.K. Chan, Li, Huan Huan, Zou, Lai-Quan, Cheung, Eric F. C., Shi, Hai-Song, Yang, Zhuo-Ya, Lui, Simon S. Y., Lui, Simon S.Y.   +17 more
core   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source