Results 71 to 80 of about 10,859,199 (331)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Construction of Electrochemical Biosensor Using Thionin-modified Electrode for Detecting Progesterone in Cattle Estrus

Electrochemistry
In the present study, a progesterone (P4) biosensor was developed to detect cattle estrus. Thionin, which has been reported to oxidize steroid hormones, was immobilized on an electrode via 10-carboxy-1-decanethiol with the aim of continuous measurement ...
Eiichiro TAKAMURA, Taiga YASHIKI, Kyouhei INADA, Kaname SUZUKI, Nobuhiro KAWAMORI, Hiroaki SAKAMOTO, Takenori SATOMURA, Shin-ichiro SUYE   +7 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effects of field crops on animals: Considerations with regard to design using Chlormequat-treated wheat crop as an example [PDF]

, 2007
There is concern whether consuming products based on crop from Chlormequat-treated fields can cause reproduction problems in animals and humans. An experiment is presently being conducted to investigate this using the pig as a model.
Højsgaard, Søren, Sørensen, Martin T.
core  

Long-term vascular access ports as a means of sedative administration in a rodent fMRI survival model [PDF]

, 2011
The purpose of this study is to develop a rodent functional magnetic resonance imaging (fMRI) survival model with the use of heparin-coated vascular access devices.
Cho, Younghoon R, Hettinger, Patrick C, Hyde, James S, Li, Rupeng, Matloub, Hani S, Pawela, Christopher P, Rowe, Daniel B., Yan, Ji-Geng   +7 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Reservoirs of Porcine Circoviruses: A Mini Review

Frontiers in Veterinary Science, 2019
Porcine circovirus (PCV) is one of the smallest known DNA viruses in mammals. At present, PCVs are divided into three species, PCV1, PCV2, and PCV3. PCV1 and PCV2 were found in the 1970s and the 1990s, respectively, whereas PCV3 was discovered recently ...
Shao-Lun Zhai, Shou-Sheng Lu, Wen-Kang Wei, Dian-Hong Lv, Xiao-Hui Wen, Qi Zhai, Qin-Ling Chen, Yan-Wei Sun, Yun Xi   +8 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Can the relation between fat and protein in milk be changed by selective breeding

Agricultural and Food Science, 1947
In Finland the protein content of the feeds is in general so low that it restricts the milk yield particularly in herds of high production capacity. This is especially significant for the reason that owing primarily to climatic factors the quality of the
T. Lonka
doaj   +2 more sources