Results 111 to 120 of about 377,815 (340)

Ethical considerations regarding animal experimentation. [PDF]

J Prev Med Hyg, 2022
Kiani AK, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Dautaj A, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M, INTERNATIONAL BIOETHICS STUDY GROUP .   +33 more
europepmc   +1 more source

The power of effective study design in animal experimentation: Exploring the statistical and ethical implications of asking multiple questions of a data set

, 2023
Rachel A. Ankeny, Alexandra L. Whittaker, Matthew Ryan, Jennifer C. Boer, Magdalena Plebanski, Jonathan Tuke, Sarah J. Spencer   +6 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Soft-robotic green sea turtle (Chelonia mydas) developed to replace animal experimentation provides new insight into their propulsive strategies. [PDF]

Sci Rep, 2023
van der Geest N, Garcia L, Borret F, Nates R, Gonzalez A.   +4 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The 3Rs Alone Will Not Reduce Total Animal Experimentation Numbers: A Fundamental Misunderstanding in Need of Correction [PDF]

, 2023
Nico Dario Müller
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Ethics and animal experimentation: what is debated?

Cadernos de Saúde Pública, 1999
The purpose of this article is to raise some points for an understanding of the contemporary debate over the ethics of using animals in scientific experiments. We present the various positions from scientific and moral perspectives establishing different
Paixão Rita Leal, Schramm Fermin Roland
doaj  

Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool. [PDF]

Pharmacol Res Perspect, 2022
Lawson R, Leymarie S, Nikitopoulos C, Humeau A, Bouchenaki H, Duroux JL, Fourcade L, Karam S, Picard N, Demiot C.   +9 more
europepmc   +1 more source

The start of sustainability in Amazonia? A new paradigm based on fertility for sustainable land management [PDF]

, 2008
In the Amazon, slash and burn is the most common technique used by American-Indians, small farmers and even big ranches to transform forests into rural landscapes.
Barbosa, Tienne, Bastos da Veiga, Jonas, De Souza Nahum, Benjamin, Quanz, Darcisio, Scopel, Eric, Sist, Plinio, Tourrand, Jean-François   +6 more
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