Results 31 to 40 of about 1,927,178 (242)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Acta Cirúrgica Brasileira, 2007 PURPOSE: To evaluate macroscopically the growth degree of self-transplantation of endometriosis in rats. METHODS: Forty female rats, after a 7-day period for adpating and evaluating of the estrous cycle regularity, underwent tail abdominal midline ...
João Nogueira Neto +5 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Ethical Aspects of Animal Experimentation [PDF]
, 1985 If inquiries are made of people regarding their attitudes towards animal experimentation, there will no doubt be various answers corresponding to the different ethical attitudes today. Three principle points of view are imaginable.
Scharmann, Wolfgang, Wolfgang Scharmann
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Confronting the bias towards animal experimentation (animal methods bias)
Frontiers in Drug DiscoveryLaws and policies are in place around the world to promote the replacement and reduction of nonhuman animals in science. These principles are rooted not just in ethical considerations for animals, but also in scientific considerations regarding the ...
Catharine E. Krebs +2 more
doaj +1 more source
Laboratory animal: biological reagent or living being?
Brazilian Journal of Medical and Biological Research, 2014 The duties of humans toward non-human animals and their rights in society have been debated for a long time. However, a discussion on the terminology used for the identification of laboratory animals is usually not considered, although the employment of ...
C.V.P. Cardoso, A.E.C.C. de Almeida
doaj +1 more source
Animals in Moral Limbo: How Literary Pigs May Help Lab-Generated Ones
Animals, 2020 When considering that artistic and literary artifacts reflect the cultural views and mores of a particular time period, there is a significant misalignment between stories depicting increased moral status of pigs (e.g., vis-à-vis human-porcine ...
Nancy Tuck
doaj +1 more source
Historical Issues Concerning Animal Experimentation in the United States
, 1981 The use of animals for research and teaching has now become an issue of great concern in the United States. In contrast to the legislative systems in Britain, Scandinavia and many European countries, American scientists can pursue research projects with ...
Sechzer, Jeri A.
core +1 more source