Results 51 to 60 of about 377,815 (340)
Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Hackney D.D. +5 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Humane Endpoints in Swiss Webster Mice Infected with Toxoplasma gondii RH Strain
AnimalsThe highly virulent Toxoplasma gondii RH strain is maintained through successive passages in mice, but there is still a lack of studies that refine these procedures from a 3Rs perspective, where humanitarian ideals aim to minimize the stress, pain, or ...
Igor Falco Arruda +7 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Smart Materials in MedicineDue to the increasing commercial activities and adventure travels, millions of people visit high-altitude regions every year. A rapid increase in altitude results in high-altitude cerebral edema (HACE), an acute form of HAI characterized by altered ...
Yaqin Chen +8 more
doaj +1 more source
Animal experimentation-Part II: In periodontal research
Journal of International Clinical Dental Research Organization, 2015 Animals contribute to the development of medical and dental sciences by being sacrificed in the hands of scientists. The experimental design demands a specific type of animal to be used for experimentation.
T K Pal
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2009 An essential book for all those who conduct animal-based research or are involved in education and training, as well as regulators, supporters, and opponents alike. This fully updated third edition includes discussion of genetically altered animals and associated welfare and ethical issues that surround the breeding programmes in animal based research.
openaire +2 more sources