Results 81 to 90 of about 162,718 (292)

FOR OUR CHILDREN: THE ETHICS OF ANIMAL EXPERIMENTATION IN THE AGE OF GENETIC ENGINEERING

, 2010
Preface -- 1. Introduction: animal experimentation, public opinion, and philosophical debate -- 2. Five ethical prototypes of animal experimentation -- 3. The case for "weak human priority" -- 4.
Nordgren, Anders
core  

Guideline Checklist for Publishing Research Papers on Animal Experimentation and Comparative Medicine in China (2024 Edition)

The standardization, transparency, and completeness of research papers in animal experimentation and comparative medicine research are crucial for ensuring the credibility, reproducibility, and clinical applicability of research findings. Internationally
Editorial Board of Laboratory Animal and Comparative Medicine
core   +1 more source

Institutional animal care and use committees and the challenges of evaluating animal research proposals

Research Integrity and Peer Review
Background In the U.S. and many other countries, animal use in research, testing, and education is under the purview of Institutional Animal Care and Use Committees or similar bodies.
John J. Pippin, Jarrod Bailey, Mark Kennedy, Deborah Dubow Press, Janine McCarthy, Ron Baron, Stephen Farghali, Elizabeth Baker, Neal D. Barnard   +8 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rabbit as an animal model for experimental research

Dental Research Journal, 2012
Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study.
Manjeet Mapara, Betsy Sara Thomas, K M Bhat   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Animal Experimentation Needs Dissection

, 1998
lette
O'Sullivan, Helen, Hill, Ruaraidh, Boyes, Edward, Stanisstreet, Martin   +3 more
core   +1 more source

Equine Activities Influence Horses’ Responses to Different Stimuli: Could This Have an Impact on Equine Welfare?

Animals, 2019
The learning and cognitive challenges that horses may face differ according to the activities in which they are involved. The aim of this investigation was to study the influence of equine activities on the behavioral responses and autonomic nervous ...
Tiago Mendonça, Cécile Bienboire-Frosini, Izabela Kowalczyk, Julien Leclercq, Sana Arroub, Patrick Pageat   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ethics for the Living World Alternative Methods and New Strategies for The Protection of Nonhuman Animals

Relations, 2013
The use of animals in laboratories is a controversial issue involving much dispute between the researchers who support animal experimentation and those who are in favor of its abolishment.
Susanna Penco, Rosagemma Ciliberti
doaj   +1 more source