Results 71 to 80 of about 4,186,252 (300)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A novel animal migration algorithm for global numerical optimization
Computer Science and Information Systems, 2016 Animal migration optimization (AMO) searches optimization solutions by migration process and updating process. In this paper, a novel migration process has been proposed to improve the exploration and exploitation ability of the animal migration ...
Qifang Luo, Mingzhi Ma, Yongquan Zhou
semanticscholar +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Introducing a unique animal ID and digital life history museum for wildlife metadata
Methods in Ecology and EvolutionOver the past five decades, a large number of wild animals have been individually identified by various observation systems and/or temporary tracking methods, providing unparalleled insights into their lives over both time and space.
Martin Wikelski +40 more
doaj +1 more source
Captivity alters behaviour but not seasonal brain size change in semi-naturally housed shrews
Royal Society Open ScienceCaptivity, frequently used in animal research, can profoundly alter brain size, cognitive abilities and activity levels. Critically, persistent exposure to stressors in captive environments can lead to chronic stress and subsequently to a range of health
Cecilia Baldoni +13 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
move2: R package for processing movement data
Methods in Ecology and EvolutionStudying animal movement is key to understanding ecological processes and studying the impacts of global change. The pivotal importance of collecting movement data drives technological development, and as a consequence, movement trajectories are gathered
Bart Kranstauber +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Antenna design using animal migration optimisation algorithm
, 2016 The use of swarm intelligence algorithms for solving complex optimisation problems is an interesting area since they can produce remarkable results. The animal migration optimisation (AMO) algorithm is one of the swarm intelligence algorithms which is ...
E. D. Ulker, S. Ulker
semanticscholar +1 more source