Results 1 to 10 of about 3,851,825 (350)
BMC Genomics, 2022 Background Quantitative real time PCR (qPCR) is a powerful tool to evaluate mRNA expression level. However, reliable qPCR results require normalization with validated reference gene(s).
Jeongah Song +3 more
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Neural stemness contributes to cell tumorigenicity
Cell & Bioscience, 2021 Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells.
Liyang Xu +7 more
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Extrapolating from Laboratory Behavioral Research on Nonhuman Primates Is Unjustified [PDF]
, 2020 Conducting research on animals is supposed to be valuable because it provides information on how human mechanisms work. But for the use of animal models to be ethically justified, it must be epistemically justified.
Crutchfield, Parker
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British Medical Bulletin, 2000 Animal models of cerebral ischaemia mimic at best less than 25% of all strokes. Compounds which prove efficacious in animal models should, therefore, only be expected to improve outcome in a quarter of all strokes. If trials for acute stroke are to succeed, stroke subgroups represented by the animal models should be targeted. For the other subgroups, e.
Small, D, Buchan, A
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Animal Models and Experimental Medicine, 2021 AbstractStroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens. As a heterogeneous disease with complex pathophysiology, mimicking all aspects of human stroke in one animal model is ...
Yanyu Li, Jingjing Zhang
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Multiple environmental controls explain global patterns in soil animal communities [PDF]
, 2020 Soil animals play important roles in ecosystem functioning and stability, but the environmental controls on their communities are not fully understood. In this study, we compiled a dataset of soil animal communities for which the abundance and body mass ...
Johnston, Alice S. A., Sibly, Richard M.
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The Journal of Reproduction and Development, 2020 Carnosic acid (CA), a natural catechol rosin diterpene, is used as an additive in animal feeds and human foods. However, the effects of CA on mammalian reproductive processes, especially early embryonic development, are unclear.
Yan-xia PENG +11 more
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Nature Communications, 2023 Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver ...
Jing Wu +12 more
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Loss of WTAP Impairs Early Parthenogenetic Embryo Development
Animals, 2021 m6A is one of the most common and abundant modifications of RNA molecules present in eukaryotes. The methyltransferase complex, consisting of methyltransferase-like 3 (METTL3), METTL14, and WTAP, is responsible for the m6A modification of RNA.
Jindong Hao +6 more
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Both prokaryotes and eukaryotes produce an immune response against plasmids with 5ʹ-GTTTGTT-3ʹ
Cell & Bioscience, 2022 In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defense gene, isg15, was activated in the ...
Nan Li +8 more
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