Results 1 to 10 of about 26,422,524 (258)
Zebrafish as an animal model for biomedical research
Experimental and Molecular Medicine, 2021 Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications.
Tae-Young Choi +4 more
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Folic acid‐induced animal model of kidney disease
Animal Models and Experimental Medicine, 2021 The kidneys are a vital organ that is vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD) which can be caused by numerous risk factors such as ischemia, sepsis, drug toxicity and drug overdose, exposure to heavy metals, and ...
Liang-Jun Yan
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BMC Genomics, 2022 Background Quantitative real time PCR (qPCR) is a powerful tool to evaluate mRNA expression level. However, reliable qPCR results require normalization with validated reference gene(s).
Jeongah Song +3 more
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Neural stemness contributes to cell tumorigenicity
Cell & Bioscience, 2021 Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells.
Liyang Xu +7 more
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Science, 2020 Protective neutralizing antibodies Antibodies produced by survivors of coronavirus disease 2019 (COVID-19) may be leveraged to develop therapies. A first step is identifying neutralizing antibodies, which confer strong protection against severe acute ...
T. Rogers +33 more
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Since SARS-CoV-2 emerged in China, it has spread rapidly around the world. Effective vaccines and therapeutics for SARS-CoV-2−induced disease (coronavirus disease 2019;COVID-19) are urgently needed.
M. Imai +33 more
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Extrapolating from Laboratory Behavioral Research on Nonhuman Primates Is Unjustified [PDF]
, 2020 Conducting research on animals is supposed to be valuable because it provides information on how human mechanisms work. But for the use of animal models to be ethically justified, it must be epistemically justified.
Crutchfield, Parker
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The Journal of Reproduction and Development, 2020 Carnosic acid (CA), a natural catechol rosin diterpene, is used as an additive in animal feeds and human foods. However, the effects of CA on mammalian reproductive processes, especially early embryonic development, are unclear.
Yan-xia PENG +11 more
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Nature Communications, 2023 Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver ...
Jing Wu +12 more
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Loss of WTAP Impairs Early Parthenogenetic Embryo Development
Animals, 2021 m6A is one of the most common and abundant modifications of RNA molecules present in eukaryotes. The methyltransferase complex, consisting of methyltransferase-like 3 (METTL3), METTL14, and WTAP, is responsible for the m6A modification of RNA.
Jindong Hao +6 more
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