Results 121 to 130 of about 2,221,657 (315)

Restricted Maximum Likelihood Estimation of Variance Components for Univariate Animal Models Using Sparse Matrix Techniques and Average Information [PDF]

open access: yes, 1995
An algorithm is described to estimate variance components for a univariate animal model using REML. Sparse matrix techniques are employed to calculate those elements of the inverse of the coefficient matrix required for the first derivatives of the ...
JOHNSON, DL, THOMPSON, R
core  

TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway

open access: yesCell Death and Disease
Overexpression of mitotic arrest deficiency 2 (MAD2/MAD2L1), a pivotal component of the spindle assembly checkpoint (SAC), resulted in many types of cancer.
Yao Xi   +14 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Animal Welfare and Eggs – Cheap Talk or Money on the Counter? [PDF]

open access: yes
We estimate revealed willingness to pay for animal welfare using a panel mixed logit model. We utilize a unique household level panel, combining real purchases with survey data on perceived public and private good attributes of different types of eggs ...
Laura Mørch Andersen
core  

MRI of Syrian hamsters reveals SARS-CoV-2 variant-specific neuroinflammation

open access: yesMicrobiology Spectrum
SARS-CoV-2 infection causes neurological manifestations in 30%–40% of patients, with reinfection exacerbating sequelae risks. Elucidating neuroinvasion mechanisms requires optimized animal models overcoming limitations of existing systems.
Yisi Tang   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Valoració per part de l’operador econòmic del model de PNT de benestar animal per a petits escorxadors d’ungulats i solípedes domèstics [PDF]

open access: yes, 2018
Benestar animal; Escorxadors; Control oficialBienestar animal; Mataderos; Control oficialAnimal welfare; Slaughterhouses; Official controlA l’anterior treball de la CoP de benestar animal (Model de PNT de benestar animal per a petits escorxadors d ...
Esquius-Calves, Marc   +8 more
core  

GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas

open access: yesCell Death and Disease
Temozolomide (TMZ), a DNA alkylating agent, has become the primary treatment for glioma, the most common malignancy of the central nervous system. Although TMZ-containing regimens produce significant clinical response rates, some patients inevitably ...
Hua He   +8 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

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