Results 131 to 140 of about 26,422,673 (403)

An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. [PDF]

, 2005
A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation.
Chen, Liangbiao, Cong, Zhe, Duan, Shumin, Gao, Hong, Guo, Lan, Guo, Li, He, Wei, Hong, Tao, Huang, Lan, Jiang, Hong, Liu, Depei, Liu, Peimao, Liu, Qian, Liu, Yali, Marasco, Wayne A, Qin, Chuan, Qu, Jianguo, Ren, Lili, Ruan, Li, She, Mingpeng, Sun, Yili, Tong, Wei, Tu, Xinming, Wang, Jianwei, Wang, Yanbin, Wei, Qiang, Yang, Renquan, Zhang, Hua, Zhang, Huiyuan, Zhang, Jianmin, Zhu, Hua   +30 more
core  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Journal of Experimental Medicine, 2007
This report shows that interleukin (IL) 17–producing T helper type 17 (Th17) cells predominantly express CC chemokine receptor (CCR) 6 in an animal model of rheumatoid arthritis (RA).
K. Hirota, H. Yoshitomi, M. Hashimoto, S. Maeda, Shin Teradaira, N. Sugimoto, Tomoyuki Yamaguchi, T. Nomura, H. Ito, Takashi Nakamura, N. Sakaguchi, S. Sakaguchi   +11 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Animal Model of Dermatophytosis

Journal of Biomedicine and Biotechnology, 2012
Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host's ...
T. Shimamura, N. Kubota, K. Shibuya
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice

Antioxidants
High-fat-diet (HFD)-induced obesity parallels hypothalamic inflammation and oxidative stress, but the correlations between them are not well-defined. Here, with mouse models targeting the antioxidant gene LanCL1 in the hypothalamus, we demonstrate that ...
Shuai Shi, Jichen Wang, Huan Gong, Xiaohua Huang, Bin Mu, Xiangyu Cheng, Bin Feng, Lanlan Jia, Qihui Luo, Wentao Liu, Zhengli Chen, Chao Huang   +11 more
doaj   +1 more source

Wild Animal Models at the Zoo [PDF]

, 1920
William T. Hornaday
openalex   +1 more source