Results 151 to 160 of about 26,422,673 (403)

Animal models of craniosynostosis

Neurochirurgie, 2019
Various animal models mimicking craniosynostosis have been developed, using mutant zebrafish and mouse. The aim of this paper is to review the different animal models for syndromic craniosynostosis and analyze what insights they have provided in our understanding of the pathophysiology of these conditions.The relevant literature for animal models of ...
D. Komla-Ebri, Emilie Dambroise, M. Biosse-Duplan, M. Cornille, Laurence Legeai-Mallet, F. Di Rocco, Nabil Kaci   +6 more
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas

Cell Death and Disease
Temozolomide (TMZ), a DNA alkylating agent, has become the primary treatment for glioma, the most common malignancy of the central nervous system. Although TMZ-containing regimens produce significant clinical response rates, some patients inevitably ...
Hua He, Lu Liang, Shiyao Jiang, Yueying Liu, Jingjing Huang, Xiaoyan Sun, Yi Li, Yiqun Jiang, Li Cong   +8 more
doaj   +1 more source

Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition

Ecotoxicology and Environmental Safety, 2023
Ferric citrate (FC) has been used as an iron fortifier and nutritional supplement, which is reported to induce colitis in rats, however the underlying mechanism remains to be elucidated.
Yu Xia, Qihui Luo, Chao Huang, Liangqin Shi, Asad Jahangir, Ting Pan, Xiaoli Wei, Junbo He, Wentao Liu, Riyi Shi, Yi Geng, Jing Fang, Li Tang, Hongrui Guo, Ping Ouyang, Zhengli Chen   +15 more
doaj  

Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C

Stem Cell Research & Therapy, 2018
Background Changes in metabolic pathway preferences are key events in the reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs).
Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li, Xiang Gao   +8 more
doaj   +1 more source

Hepatotoxicity and Halothane Metabolism in an Animal Model with Application for Human Toxicity [PDF]

, 1979
Michael J. Cousins, James H. Sharp, Geoffrey K. Gourlay, John Adams, W.D.G. Haynes, Richard Whitehead   +5 more
openalex   +1 more source

Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection [PDF]

, 1975
M. Scriba
openalex   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Neuropathy in experimental diabetes: an animal model. [PDF]

, 1976
Johannes Jakobsen, K Lundbæk
openalex   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source