Results 171 to 180 of about 27,577,089 (399)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota regulates serum metabolites in mice with nonalcoholic fatty liver disease via gut metabolites: mechanisms involving branched-chain amino acids and unsaturated fatty acids

Frontiers in Endocrinology
IntroductionIn recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease.
Hao Qiu, Hao Qiu, Yuhang Wen, Yuhang Wen, Yadan Luo, Yadan Luo, Shuya Lv, Shuya Lv, Jingrong Huang, Jingrong Huang, Baoting Chen, Baoting Chen, Ruilin Lu, Ruilin Lu, Lvqin He, Lvqin He, Qian Yang, Qian Yang, Jianhong Han, Jianhong Han, Xuefeng Yan, Xuefeng Yan, Manli He, Manli He, Mingde Zhao, Mingde Zhao, Xiaoxia Zou, Xiaoxia Zou, Congwei Gu, Congwei Gu, Congwei Gu   +30 more
doaj   +1 more source

Animal models [PDF]

Nature, 1987
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Pharmacological effects of two polar fractions from Annona coriacea Mart in animal models

, 2012
Orlando Vieira de Sousa
openalex   +1 more source

Understanding animal fears: a comparison of the cognitive vulnerability and harm-looming models [PDF]

, 2007
Jason M. Armfield
openalex   +1 more source

Targeting α6GABAA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models

, 2022
Ming Tatt Lee, Akihiro Mouri, Hisayoshi Kubota, Hsin‐Jung Lee, Man‐Hsin Chang, Chen-Yi Wu, Daniel E. Knutson, Marko D. Mihovilovič, James M. Cook, Werner Sieghart, Toshitaka Nabeshima, Lih‐Chu Chiou   +11 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance [PDF]

, 2017
Juliane de Souza Cardoso, Pathise Souto Oliveira, Natália Pontes Bona, Flávia Aleixo Vasconcellos, Jucimara Baldissarelli, M. Vizzotto, Mayara Sandrielly Pereira Soares, Vanessa Plasse Ramos, Rosélia Maria Spanevello, Claiton Leoneti Lencina, Rejane Giacomelli Tavares, Francieli Moro Stefanello   +11 more
openalex   +1 more source