Results 11 to 20 of about 1,981,363 (314)
Animal Models and Experimental Medicine, 2021 AbstractStroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens. As a heterogeneous disease with complex pathophysiology, mimicking all aspects of human stroke in one animal model is ...
Yanyu Li, Jingjing Zhang
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PER1 Phosphorylation Specifies Feeding Rhythm in Mice
Cell Reports, 2014 Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS).
Zhiwei Liu +10 more
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Scientific Reports, 2022 The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park +5 more
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ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans
Nature Communications, 2023 Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang +12 more
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Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation
Cell Discovery, 2022 Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou +10 more
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Animal Models in Osteosarcoma [PDF]
Frontiers in Oncology, 2014 Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for non-metastatic disease approaching 70%. However, most OS tumors are high grade and tend to rapidly develop pulmonary metastases.
Guijarro, Maria V. +2 more
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BMC Cancer, 2023 Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu +11 more
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The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Journal of Neuroinflammation, 2019 Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu +5 more
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204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析
Journal of Diabetes, 2022 Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu +8 more
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Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells
Cell Reports, 2018 Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang +8 more
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