Results 11 to 20 of about 1,971,298 (262)

PER1 Phosphorylation Specifies Feeding Rhythm in Mice

Cell Reports, 2014
Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS).
Zhiwei Liu, Moli Huang, Xi Wu, Guangsen Shi, Lijuan Xing, Zhen Dong, Zhipeng Qu, Jie Yan, Ling Yang, Satchidananda Panda, Ying Xu   +10 more
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Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

Scientific Reports, 2022
The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park, Goo-Hwa Kang, Youngkyu Kim, Ju Young Lee, Jeong Ah Song, Jeong Ho Hwang   +5 more
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ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans

Nature Communications, 2023
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang, Lina Zou, Yiyan Zhang, Mengnan Zhu, Shuxian Zhang, Di Wu, Jianfeng Lan, Xiao Zang, Qi Wang, Hanxin Zhang, Zixing Wu, Huanhu Zhu, Di Chen   +12 more
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Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
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The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

Journal of Neuroinflammation, 2019
Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao   +5 more
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204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析

Journal of Diabetes, 2022
Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu, Wenxin Wang, Xuewei Huang, Xingyuan Zhang, Lijin Lin, Juan‐Juan Qin, Fang Lei, Jingjing Cai, Bo Cheng   +8 more
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Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells

Cell Reports, 2018
Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang, Wukui Zhao, Congcong Wang, Yaru Zhu, Mengjie Liu, Huan Tong, Yin Xia, Qing Jiang, Jinzhong Qin   +8 more
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Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

BMC Cancer, 2023
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun, Guohua Song   +11 more
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A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

EBioMedicine, 2020
Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou, Jingwen Pei, Jianfeng Lan, Hong Sang, Hongjuan Chen, Haoliang Yuan, Di Wu, Yuanyuan Zhang, Yufang Wang, Dingyu Wang, Yujie Zou, Di Chen, Jianan Ren, Xiang Gao, Zhaoyu Lin   +14 more
doaj   +1 more source

Modelling Farm Animal Welfare [PDF]

Animals, 2013
The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research.
Lisa Collins, Cherie E. Part
openaire   +5 more sources