Results 11 to 20 of about 25,135,144 (317)
Both prokaryotes and eukaryotes produce an immune response against plasmids with 5ʹ-GTTTGTT-3ʹ
Cell & Bioscience, 2022 In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defense gene, isg15, was activated in the ...
Nan Li +8 more
doaj +1 more source
Zebrafish as an alternative animal model in human and animal vaccination research
Laboratory Animal Research, 2020 Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies.
R. Bailone +8 more
semanticscholar +1 more source
Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction
Frontiers in Physiology, 2020 Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined.
Jie Sun +13 more
doaj +1 more source
Journal of Immunology Research, 2022 Background. Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC) and one of the leading causes of cancer-related death worldwide. LUAD has a low survival rate owing to tumour invasion and metastasis.
Lu Liang +7 more
doaj +1 more source
Methoxychlor induces oxidative stress and impairs early embryonic development in pigs
Frontiers in Cell and Developmental Biology, 2023 Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly used worldwide as an insecticide against pests and mosquitoes. However, MXC is not biodegradable and has lipophilic characteristics; thus, it accumulates in organisms
Zhaojun Geng +10 more
doaj +1 more source
PER1 Phosphorylation Specifies Feeding Rhythm in Mice
Cell Reports, 2014 Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS).
Zhiwei Liu +10 more
doaj +1 more source
Scientific Reports, 2022 The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park +5 more
doaj +1 more source
ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans
Nature Communications, 2023 Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang +12 more
doaj +1 more source
Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation
Cell Discovery, 2022 Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou +10 more
doaj +1 more source
BMC Cancer, 2023 Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu +11 more
doaj +1 more source