Results 11 to 20 of about 26,422,673 (403)
British Medical Bulletin, 2000 Animal models of cerebral ischaemia mimic at best less than 25% of all strokes. Compounds which prove efficacious in animal models should, therefore, only be expected to improve outcome in a quarter of all strokes. If trials for acute stroke are to succeed, stroke subgroups represented by the animal models should be targeted. For the other subgroups, e.
Small, D, Buchan, A
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Animal Models and Experimental Medicine, 2021 AbstractStroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens. As a heterogeneous disease with complex pathophysiology, mimicking all aspects of human stroke in one animal model is ...
Yanyu Li, Jingjing Zhang
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Journal of Immunology Research, 2022 Background. Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC) and one of the leading causes of cancer-related death worldwide. LUAD has a low survival rate owing to tumour invasion and metastasis.
Lu Liang +7 more
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Both prokaryotes and eukaryotes produce an immune response against plasmids with 5ʹ-GTTTGTT-3ʹ
Cell & Bioscience, 2022 In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defense gene, isg15, was activated in the ...
Nan Li +8 more
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Methoxychlor induces oxidative stress and impairs early embryonic development in pigs
Frontiers in Cell and Developmental Biology, 2023 Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly used worldwide as an insecticide against pests and mosquitoes. However, MXC is not biodegradable and has lipophilic characteristics; thus, it accumulates in organisms
Zhaojun Geng +10 more
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Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction
Frontiers in Physiology, 2020 Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined.
Jie Sun +13 more
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An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury.
New England Journal of Medicine, 2020 An Animal Model of EVALI In this study, investigators developed a mouse model of e-cigarette, or vaping, product use–associated lung injury.
T. A. Bhat +5 more
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Multiple environmental controls explain global patterns in soil animal communities [PDF]
, 2020 Soil animals play important roles in ecosystem functioning and stability, but the environmental controls on their communities are not fully understood. In this study, we compiled a dataset of soil animal communities for which the abundance and body mass ...
Johnston, Alice S. A., Sibly, Richard M.
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Zebrafish as an alternative animal model in human and animal vaccination research
Laboratory Animal Research, 2020 Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies.
R. Bailone +8 more
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Animal models of preeclampsia [PDF]
Seminars in Nephrology, 1999 There have been many attempts to produce animal models that mimic the hypertensive disorders of pregnancy, especially preeclampsia, but most are incomplete when compared to the full spectrum of the human disease. This review assesses a number of these models, organized according to the investigators attempt to focus on a specific pathogenic mechanism ...
Chris Baylis +8 more
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