Results 31 to 40 of about 25,135,144 (317)

The role of the gut microbiota on animal model reproducibility

Animal Models and Experimental Medicine, 2018
The gut microbiota is composed of approximately 1010‐1014 cells, including fungi, bacteria, archaea, protozoa, viruses, and bacteriophages; their genes and their various metabolites were found throughout the gastrointestinal tract. It has co‐evolved with
P. Turner
semanticscholar   +1 more source

Logical fallacies in animal model research

Behavioral and Brain Functions, 2017
BackgroundAnimal models of human behavioural deficits involve conducting experiments on animals with the hope of gaining new knowledge that can be applied to humans.
Espen A. Sjoberg
semanticscholar   +1 more source

6-Gingerol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress

Animals, 2023
6-Gingerol, the main active ingredient in ginger, exhibits a variety of biological activities, such as antioxidant, anti-inflammatory, and anticancer activities, and can affect cell development.
Wenjie Yu, Yanxia Peng, Xinyue Peng, Ze Li, Chang Liu, Liu Yang, Yan Gao, Shuang Liang, Bao Yuan, Chengzhen Chen, Nam-hyung Kim, Hao Jiang, Jiabao Zhang   +12 more
doaj   +1 more source

The molecular basis of the genesis of basal tone in internal anal sphincter

Nature Communications, 2016
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2 ...
Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu   +19 more
doaj   +1 more source

Exploring the Validity of Valproic Acid Animal Model of Autism

Experimental Neurobiology, 2015
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism?
Darine Froy N. Mabunga, E. L. Gonzales, Ji-Woon Kim, Ki Chan Kim, C. Shin   +4 more
semanticscholar   +1 more source

TBX2 affects proliferation, apoptosis and cholesterol generation by regulating mitochondrial function and autophagy in bovine cumulus cell

Veterinary Medicine and Science, 2023
Background T‐box transcription factor 2 (TBX2) is a member of T‐box gene family whose members are highly conserved in evolution and encoding genes and are involved in the regulation of developmental processes. The encoding genes play an important role in
Sheng‐Peng Li, Hao Jiang, Zi‐Bin Liu, Wen‐Jie Yu, Xiao‐Shi Cai, Chang Liu, Wen‐Yin Xie, Fu‐shi Quan, Wei Gao, Nam‐Hyung Kim, Bao Yuan, Cheng‐Zhen Chen, Jia‐Bao Zhang   +12 more
doaj   +1 more source

Freshwater Planarians as an Alternative Animal Model for Neurotoxicology.

Toxicological Sciences, 2015
Traditional toxicology testing has relied on low-throughput, expensive mammalian studies; however, timely testing of the large number of environmental toxicants requires new in vitro and in vivo platforms for inexpensive medium- to high-throughput ...
D. Hagstrom, O. Cochet-Escartin, Siqi Zhang, Cindy D. Khuu, Eva-Maria S. Collins   +4 more
semanticscholar   +1 more source

HAX1 inhibits apoptosis and promotes maturation of neutrophils

Cell Communication and Signaling
As the diverse functions of neutrophils continue to be uncovered, elucidating the molecular mechanisms that regulate their differentiation, development, and apoptosis has become crucial for overcoming limitations in the treatment of neutrophil-related ...
Hanwei Yue, Guiying Shi, Jiaming Tang, Xinyue Li, Lin Bai   +4 more
doaj   +1 more source

Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders

Population Ecology, EarlyView.
We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa, Andrea Costa, Sebastiano Salvidio   +2 more
wiley   +1 more source

Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors

Population Ecology, EarlyView.
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley   +1 more source