Results 31 to 40 of about 27,577,089 (399)

A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

EBioMedicine, 2020
Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou, Jingwen Pei, Jianfeng Lan, Hong Sang, Hongjuan Chen, Haoliang Yuan, Di Wu, Yuanyuan Zhang, Yufang Wang, Dingyu Wang, Yujie Zou, Di Chen, Jianan Ren, Xiang Gao, Zhaoyu Lin   +14 more
doaj   +1 more source

Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

BMC Cancer, 2023
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun, Guohua Song   +11 more
doaj   +1 more source

Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells

Cell Reports, 2018
Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang, Wukui Zhao, Congcong Wang, Yaru Zhu, Mengjie Liu, Huan Tong, Yin Xia, Qing Jiang, Jinzhong Qin   +8 more
doaj   +1 more source

Collective Animal Behavior from Bayesian Estimation and Probability Matching [PDF]

, 2011
Animals living in groups make movement decisions that depend, among other factors, on social interactions with other group members. Our present understanding of social rules in animal collectives is based on empirical fits to observations and we lack ...
A Houston, A Oaten, AC Courville, AJ King, AJW Ward, AJW Ward, Alfonso Pérez-Escudero, B Doligez, C Clark, CAH Bousquet, CJ Proctor, D Alais, DC Knill, DC Knill, DJ Sumpter, DJT Sumpter, DR Wozny, E Mach, ER Behrend, ET Jaynes, G Box, G Rieucau, G Schwarz, Gonzalo G. de Polavieja, H Helmholtz, I Coolen, Iain D. Couzin, ID Couzin, ID Couzin, ID Couzin, ID Couzin, J Alonso, J Neyman, J Staddon, JA Marshall, JB Tenenbaum, JI Gold, JI Gold, JJ Templeton, JJ Templeton, JK Kruschke, JM Biernaskie, JM McNamara, JW Smith, KL Kirk, KP Kording, KP Körding, LA Giraldeau, MO Ernst, N Vulkan, Nordell, PW Battaglia, R Herrnstein, R Jacobs, R Jeanson, RH Wagner, S Blanchet, S Fretwell, SL Lima, SRX Dall, T Boulinier, TJ Valone, TJ Valone, TJ Valone, U Greggers, W Gaissmaier, WA Link, Y Katz, Y van Bergen   +68 more
core   +10 more sources

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

Frontiers in Immunology, 2019
Infectious diseases still remain one of the biggest challenges for human health. In order to gain a better understanding of the pathogenesis of infectious diseases and develop effective diagnostic tools, therapeutic agents, and preventive vaccines, a ...
Jinxin Miao, Louisa S. Chard, Zhimin Wang, Yaohe Wang   +3 more
semanticscholar   +1 more source

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. [PDF]

, 2017
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an ...
Freeman, Lisa M, Huggins, Gordon S, Maron, Martin S, Rush, John E, Stern, Joshua A   +4 more
core   +2 more sources

Choosing the right animal model for infectious disease research

Animal Models and Experimental Medicine, 2018
A complex biological system is often required to study the myriad of host‐pathogen interactions associated with infectious diseases, especially since the current basis of biology has reached the molecular level.
J. Swearengen
semanticscholar   +1 more source

The 2020 Five Domains Model: Including Human–Animal Interactions in Assessments of Animal Welfare

Animals, 2020
Simple Summary This review outlines the latest in a succession of updates of the Five Domains Model, which, at each stage, incorporated contemporary verified scientific thinking of relevance to animal welfare assessment.
D. Mellor, N. Beausoleil, K. Littlewood, A. McLean, P. McGreevy, B. Jones, C. Wilkins   +6 more
semanticscholar   +1 more source

Role of animal models in biomedical research: a review

Laboratory Animal Research, 2022
The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human.
P. Mukherjee, S. Roy, D. Ghosh, S. Nandi
semanticscholar   +1 more source

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska, Delanghe, Joris, Devreese, Mathias, Gasthuys, Elke, Heyndrickx, Marjolein, Millecam, Joske, Sys, Stanislas, Vande Walle, Johan, Vanderperren, Katrien   +8 more
core   +3 more sources