Results 81 to 90 of about 3,095,140 (302)
Scientific ReportsIn laboratory animals, there is a scarcity of digestibility data under non-experimental conditions. Such data is important as basis to generate nutrient requirements, which contributes to the refinement of husbandry conditions.
Linda F. Böswald +2 more
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AnimalsPolystyrene microplastics (PS-MPs) are microplastic particles produced during plastic manufacturing and environmental degradation, accumulating over time and entering ecosystems through various pathways, ultimately affecting organisms and inducing toxic ...
Hui-Mei Huang +7 more
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Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]
, 2018 The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski +11 more
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment
Frontiers in PharmacologyBackgroundFerroptosis is an intracellular iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Increasing evidence indicated that ferroptosis plays a crucial role in suppressing tumors, thus providing new opportunities for ...
Jing-Song Guan +9 more
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Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Journal of Experimental & Clinical Cancer Research, 2019 Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
doaj +1 more source
Virology Journal, 2020 Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu +6 more
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Flexible and practical modeling of animal telemetry data: hidden Markov models and extensions [PDF]
, 2012 We discuss hidden Markov-type models for fitting a variety of multistate random walks to wildlife movement data. Discrete-time hidden Markov models (HMMs) achieve considerable computational gains by focusing on observations that are regularly spaced in ...
Langrock, R. +5 more
core +3 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Microfluidics : the fur-free way towards personalised medicine in cancer therapy [PDF]
, 2016 Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients.
Bower, Ruth +3 more
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