Results 71 to 80 of about 2,537,384 (294)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Membrane Interactions of Nano-Silica and Its Potential Application in Animal Nutrition

, 2019
Nanoparticles are increasingly popular in numerous fields including electronics, optics and medicine (vaccines, tissue engineering, microsurgery, genomics and cancer therapies).
Marek Pieszka, Dorota Bederska-Łojewska, Magdalena Pieszka, Paulina Szczurek   +3 more
core   +1 more source

Research Progress on Lycopene in Swine and Poultry Nutrition: An Update

, 2023
Oxidative stress and in-feed antibiotics restrictions have accelerated the development of natural, green, safe feed additives for swine and poultry diets. Lycopene has the greatest antioxidant potential among the carotenoids, due to its specific chemical
Jinming You, Jun Chen, Xingping Chen, Xuehai Cao, Zhouyin Huang, Tiande Zou   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Probiotic efficacy of Cetobacterium somerae (CGMCC No. 28843): promoting intestinal digestion, absorption, and structural integrity in juvenile grass carp (Ctenopharyngodon idella)

Journal of Animal Science and Biotechnology
Background Cetobacterium somerae, a symbiotic microorganism resident in various fish intestines, is recognized for its beneficial effects on fish gut health. However, the mechanisms underlying the effects of C. somerae on gut health remain unclear.
Yuanxin Chen, Weidan Jiang, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Jun Jiang, Ruinan Zhang, Hua Li, Lin Feng, Xiaoqiu Zhou   +11 more
doaj   +1 more source

Innovative swine nutrition: some present and potential applications of latest scientific findings for safe pork production

Italian Journal of Animal Science, 2010
One of the biggest challenges facing animal agriculture in the 21st century is to produce safe and traceable foodstuffs of animal origin in sufficient volumes and quality besides the lowest possible load on the environment.
Veronika Halas, László Babinszky
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Glutamine relieves feed restriction-induced ruminal epithelial function damage through histone lysine lactylation in yaks

Journal of Animal Science and Biotechnology
Background As a unique livestock adapted to the harsh environment, grazing yaks frequently suffer from malnutrition and even death because of the lower yield and quality of forage in the Qinghai-Tibet Plateau during the cold season.
Ziqi Yue, Liyuan Shi, Zhisheng Wang, Rui Hu, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +9 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Dietary xylooligosaccharides modulate oxidative stress and pathogen resistance in growing rabbits

Journal of Animal Science and Biotechnology
Background Given the high incidence of gastrointestinal disorders in intensive rabbit production, we assessed the effects of graded levels of xylooligosaccharides (XOS) on growth performance, nutrient digestibility and intestinal health in growing ...
Aipeng Mao, Xiaoyan Peng, Junning Pu, Yanbin Chen, Qingyue Liu, Jingyi Cai, Hua Zhao, Gang Jia, Gang Tian   +8 more
doaj   +1 more source