Results 81 to 90 of about 2,537,384 (294)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Exploring new benefits of vitamin A: alleviating hypoxia-induced mitochondrial stress and mitophagy in the gills of adult grass carp (Ctenopharyngodon idellus)

Journal of Animal Science and Biotechnology
Background Hypoxia is a pervasive challenge in aquaculture that poses a significant threat to aquatic organisms. Since fish cannot synthesize vitamin A endogenously, it must be supplied through diet, and it plays a vital role in supporting fish stress ...
Hua Cheng, Lin Feng, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Xiaoqiu Zhou, Weidan Jiang   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Enzymes in Animal Nutrition and Terms of Activity

, 2012
Moran, Ed. (2012). Enzymes in Animal Nutrition and Terms of Activity.
Moran, Ed
core  

Curcumin attenuates ochratoxin A and hypoxia co-induced liver injury in grass carp (Ctenopharyngodon idella) by dual targeting endoplasmic reticulum stress and apoptosis via reducing ROS content

Journal of Animal Science and Biotechnology
Background Ochratoxin A (OTA) is a toxin widely found in aquafeed ingredients, and hypoxia is a common problem in fish farming. In practice, aquatic animals tend to be more sensitive to hypoxia while feeds are contaminated with OTA, but no studies exist ...
Liangqin Wu, Piao Zhao, Pei Wu, Weidan Jiang, Yang Liu, Hongmei Ren, Xiaowan Jin, Xiaoqiu Zhou, Lin Feng   +8 more
doaj   +1 more source

Animal Nutrition and Productions: Series II

Agriculture
The Food and Agriculture Organization of the United Nations estimates that by 2050, there will be a 58% increase in dairy consumption and a 73% increase in meat and egg consumption, worldwide, which would put additional pressure on the availability of ...
Daniel Simeanu, Răzvan-Mihail Radu-Rusu, Adrian Maximilian Macri, Daniel Mierliță   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Methionine deficiency inhibited pyroptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella): possibly via activating the ROS-AMPK-autophagy axis

Journal of Animal Science and Biotechnology
Background Methionine (Met) is the only sulfur-containing amino acid among animal essential amino acids, and methionine deficiency (MD) causes tissue damage and cell death in animals.
Yuanlin He, Pei Wu, Weidan Jiang, Yang Liu, Xiaowan Jin, Hongmei Ren, Ruinan Zhang, Xiaoqiu Zhou, Lin Feng   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway

Journal of Animal Science and Biotechnology
Background The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing rabbits under summer heat.
Zimei Li, Junning Pu, Xiang Chen, Yanbin Chen, Xiaoyan Peng, Jingyi Cai, Gang Jia, Hua Zhao, Gang Tian   +8 more
doaj   +1 more source