Results 71 to 80 of about 20,896 (257)

H²RSPET: a 0.5 mm resolution high-sensitivity small-animal PET scanner, a simulation study. [PDF]

Phys Med Biol, 2021
Lai Y, Wang Q, Zhou S, Xie Z, Qi J, Cherry SR, Jin M, Chi Y, Du J.   +8 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Prototype Small-Animal PET-CT Imaging System for Image-Guided Radiation Therapy

IEEE Access, 2019
Molecular imaging is becoming essential for precision targeted radiation therapy, yet progress is hindered from a lack of integrated imaging and treatment systems.
Ekaterina Mikhaylova, Jamison Brooks, Darren M. Zuro, Farouk Nouizi, Maciej Kujawski, Srideshikan Sargur Madabushi, Jinyi Qi, Mengxi Zhang, Junie Chea, Erasmus K. Poku, Nicole Bowles, Jeffrey Y. C. Wong, John E. Shively, Paul J Yazaki, Gultekin Gulsen, Simon R. Cherry, Susanta K. Hui   +16 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Pet-Compton system. Comparative evaluation with PET system using Monte Carlo simulation

Nucleus, 2012
Positron Emission Tomography (PET) in small animals has actually achieved spatial resolution round about 1 mm and currently there are under study different approaches to improve this spatial resolution.
Angelina Díaz García, Juan A. Rubio Rodríguez, José M. Pérez Morales, Pedro Arce Dubois, Oscar Vela Morales, Eduardo Arista Romeu   +5 more
doaj  

Preclinical Evaluation of Ga-DOTA-Minigastrin for the Detection of Cholecystokinin-2/Gastrin Receptor-Positive Tumors

Molecular Imaging, 2011
In comparison to somatostatin receptor scintigraphy, gastrin receptor scintigraphy using 111 In-DTPA-minigastrin (MG0) showed added value in diagnosing neuroendocrine tumors.
Maarten Brom, Lieke Joosten, Peter Laverman, Wim J.G. Oyen, Martin Béhé, Martin Gotthardt, Otto C. Boerman   +6 more
doaj   +1 more source

[18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of LAPC4-CR Castration-Resistant Prostate Cancer Xenograft Model in Soft Tissue Compartments

Translational Oncology, 2015
Preclinical xenograft models have contributed to advancing our understanding of the molecular basis of prostate cancer and to the development of targeted therapy. However, traditional preclinical in vivo techniques using caliper measurements and survival
Keisha C. McCall, Su-Chun Cheng, Ying Huang, Nancy E. Kohl, Tanya Tupper, Annick D. Van den Abbeele, Katherine A. Zukotynski, Christopher J. Sweeney   +7 more
doaj   +1 more source

Spatial resolution of the Inveon small-animal PET scanner for the entire field of view

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010
In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV).
Disselhorst, J.A., Boerman, O.C., Oyen, W.J.G., Slump, C.H., Visser, E.P.   +4 more
openaire   +3 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source