Results 61 to 70 of about 1,415,177 (267)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A simplified feeding system did not affect milk production compared with a total mixed ration system in dairy cows

Italian Journal of Animal Science, 2020
The objective of our study was to compare animal performance of a simplified feeding system, named easy feeding (EF), with animal performance of a total mixed ration (TMR) feeding system, using high yielding dairy cows in early lactation. Two treatments,
Maira Cuffia, Javier Baudracco, Luis Romero, Alejandra Cuatrin, Gerardo Gagliostro, Jose Maiztegui, Eduardo Comerón   +6 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows

BMC Veterinary Research, 2019
Background The aim of this study was to investigate the association between plasma β-hydroxybutyric acid (BHBA) and conjugated linoleic acid in postpartum Polish Holstein-Friesian (PHF) cows.
Kamila Puppel, Marcin Gołębiewski, Paweł Solarczyk, Grzegorz Grodkowski, Jan Slósarz, Małgorzata Kunowska-Slósarz, Marek Balcerak, Tomasz Przysucha, Aleksandra Kalińska, Beata Kuczyńska   +9 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Effects of quadric probiotic blends on rumen fermentation, nutrient degradability, and methane emission in sheep: an in vitro study

AMB Express
The considerable contribution of ruminant livestock to methane emissions has become a major global concern in recent years. Although dietary approaches for reducing ruminant methane emissions have been explored, the sustainable potential of probiotics to
Ali S. A. Saleem, Khaled M. Al-Marakby, Mohamed Y. Elaref, Sabry M. Bassiony, Amera A. Helal, Usama M. Abdel-Monem, Sameh A. Abdelnour   +6 more
doaj   +1 more source

Factors affecting growth traits of beef cattle breeds raised inSlovakia

Czech Journal of Animal Science, 2005
Growth traits of purebred calves of six beef breeds (Aberdeen Angus - AA, Blonde d'Aquitaine - BA, Charolais - CH,Hereford - HE, Limousine - LI and Beef Simmental - BS) born from 1998 to 2002 were analysed.
E. Krupa, M. Oravcová, P. Polák, J. Huba, Z. Krupová   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source