Results 121 to 130 of about 321,984 (308)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Trade-offs between conflicting animal welfare concerns and cow replacement strategy in out-wintering Scottish suckler herds [PDF]
Since decoupling of the CAP, many Scottish suckler cow farms are facing financial difficulties. In response, many farmers are out-wintering extensively managed suckler cows to minimise production costs. These systems are of animal welfare concern.
Vosough Ahmadi, Bouda +2 more
core +1 more source
Use of Torula Yeast from Sugar Cane Molasses in White Leghorn Replacement Hens.
Revista de Producción Animal, 2015 The use of Torula yeast from sugar cane molasses in the diet of White Leghorn replacement chicks L-33 was eva-luated. Two hundred 15-20 week-old chicks were used in a completely randomized design, comprising 4 treatments (10 birds per cage).
Jorge E. Gómez Cuello
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Normas de bem-estar animal: da academia aos agentes sanitaristas [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em AgroecossistemasAs questões relativas às condições de bem-estar dos animais, durante os últimos anos, vêm sendo abordadas com mais ...
Improta, Clovis Thadeu Rabello
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The New Economics of Livestock Production Management [PDF]
The importance of heterogeneity of animal attributes in livestock production is assessed. Preliminary results indicate that variance and skew measures of attributes may be becoming more important over time.livestock economics, herd management, livestock ...
Hubbs, Todd +6 more
core +1 more source
Are animals – and persons – morally “replaceable”?
Ethics & BioethicsAbstract This article critically examines Peter Singer’s arguments for two conclusions: first, that non-self-conscious animals are “replaceable” in the sense that the killing of one can be morally offset by the creation of another; and, second, that persons are not replaceable in this sense.
openaire +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Dar in “Machine crushed animal bones as partial replacement of coarse aggregates in lightweight concrete [PDF]
, 2020 An exploratory study on the suitability of the machine crushed animal bones as partial or full replacement for normal coarse aggregates in concrete works has been carried out. Physical and mechanical properties of machine crushed animal bones and locally
Reyaz Ahmad Qasab +2 more
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