Results 211 to 220 of about 311,505 (261)
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Brazil Moves Toward the Replacement of Animal Experimentation
ATLA Alternatives To Laboratory Animals, 2019In Brazil, efforts towards the regulatory acceptance and implementation of innovative methods to replace experimental animal use in various fields began to gather force in 2008, with the approval of Law No. 11,794/2008 (the Arouca Law). This law represented a milestone, as it created the National Council for the Control of Animal Experimentation ...
Renato Ivan de Ávila, Valadares Mc
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Management of Replacement Breeding Animals
Veterinary Clinics of North America: Food Animal Practice, 1992In conclusion, replacement gilts should be finally selected before 110 kg body weight and should have been stimulated to reach puberty by this time. Currently, the best method for achieving this is ad libitum feeding and the correct use of boar exposure.
R N, Kirkwood, P A, Thacker
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Strategies for replacing animals in biomedical research
Molecular Medicine Today, 1997In 1959, Russell and Burch published their recommendations for applying the Three Rs (reduction, refinement and replacement alternatives) to the use of animals in scientific experimentation. At this time, they could not have predicted the effect of this fundamental concept on academic and industrial animal experimentation and in biomedical education ...
C L, Broadhead, K, Bottrill
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The Replacement of Animal Tests
Alternatives to Laboratory Animals, 2018Progress toward the acceptance and application of validated alternative test methods as replacements for animal tests, is being frustrated by the unsatisfactory procedures involved in approving new test guidelines and deleting existing ...
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Replacing animal experiments: choices, chances and challenges
BioEssays, 2007AbstractReplacing animal procedures with methods such as cells and tissues in vitro, volunteer studies, physicochemical techniques and computer modelling, is driven by legislative, scientific and moral imperatives. Non‐animal approaches are now considered as advanced methods that can overcome many of the limitations of animal experiments.
Langley, Gill +3 more
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Pulmonary in vitro instruments for the replacement of animal experiments
European Journal of Pharmaceutics and Biopharmaceutics, 2021Advanced in vitro systems often combine a mechanical-physical instrument with a biological component e.g. cell culture models. For testing of aerosols, it is of advantage to consider aerosol behavior, particle deposition and lung region specific cell lines.
Daniel, Primavessy +5 more
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Towards Finding Animal Replacement Methods
2017Protecting animal rights and reducing animal suffering in experimentation is a globally recognized goal in science. Yet numbers have been rising, especially in basic research. While most scientists agree that they would prefer to use less invasive methods, studies have shown that current information systems are not equipped to support the search for ...
Dulisch, Nadine, Mathiak, Brigitte
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Animal Studies of Surfactant Replacement Therapy
Developmental Pharmacology and Therapeutics, 2017Before using surfactant preparations in animal experiments or in clinical trials, it is necessary that they fulfil specific in vivo requirements. But conclusive criteria for the effectiveness of a surfactant have not yet been defined. Thus, some standard levels for improvement of lung function, or threshold levels, must be established in standardized ...
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Thyroxine replacement in an animal model of congenital hypothyroidism
Physiology & Behavior, 2007This study examined the effects of thyroxine (T(4)) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T(4) (vehicle) treatment (n=12), T(4) treatment commencing on postnatal day (P-) 7 (n=14), and T(4) treatment commencing on P ...
Reid, R.E. +4 more
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1989
People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
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People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
openaire +1 more source