Results 221 to 230 of about 311,505 (261)

Non-animal Replacements for Acute Toxicity Testing

Alternatives to Laboratory Animals, 2015
Current approaches to predicting adverse effects in humans from acute toxic exposure to cosmetic ingredients still heavily necessitate the use of animals under EU legislation, particularly in the context of the REACH system, when cosmetic ingredients are also destined for use in other industries.
Carol, Barker-Treasure, Kevin, Coll, Nathalie, Belot, Chris, Longmore, Karl, Bygrave, Suzanne, Avey, Richard, Clothier   +6 more
openaire   +2 more sources

Diaphragm replacement – an experimental animal study

Langenbecks Archiv für Chirurgie, 1997
We performed an open experimental study for evaluation of rapidly absorbable material of bovine serosa for diaphragm replacement. A total of 100 Sprague-Dawley rats were randomly assigned to five groups of equal size. In the control group (n=20) incision of the diaphragm was followed by primary suture.
G. Steinau, B. Dreuw, J. Schleef, V. Schumpelick   +3 more
openaire   +2 more sources

HPLC as a replacement for the animal response assays for insulin

Journal of Pharmaceutical and Biomedical Analysis, 1986
The work describes the assay of the potency of insulin (drug substance) and its formulations by gradient elution reversed-phase high-performance liquid chromatography (HPLC). The methods are shown to differentiate between insulins of bovine, porcine and human sequence, and to be both reproducible and stability-indicating.
B V, Fisher, D, Smith
openaire   +2 more sources

Replacing experiments on laboratory animals

Trends in Biochemical Sciences, 1986
There is great scope for overcoming the moral dilemma inherent in experiments using live animals by reducing the numbers of animals required, minimizing any suffering caused, and, in many cases, replacing them altogether through the development, validation and application of alternative methods.
openaire   +1 more source

Technology Feature | Replacing the replacements: Animal model alternatives

Science, 2018
Advances in biosensors and microfluidic devices are driving a quiet revolution in biomedical research, which could lead to the reduction or elimination of animal use in many experiments..
openaire   +1 more source

Trends in Animal Use and Replacement in the ‘Three Is’ of Industry

Alternatives to Laboratory Animals, 2012
The chemical industry has much to learn from the cosmetics and pharmaceutical industries about the replacement of animal ...
openaire   +2 more sources

In-vitro techniques: can they replace animal testing?*

Human Reproduction, 1986
In-vitro tests for the long-term safety evaluation of drugs offer certain advantages. Specific properties of drugs can be identified including mutagenic and carcinogenic effects. The mechanisms leading to toxicity can be assessed. Tissue from several species, including man, can be examined.
openaire   +2 more sources

New models in cosmetics replacing animal testing

Communications of the ACM, 2014
A European law spurs scientists to develop computational simulations capable of predicting the toxicity of cosmetics.
openaire   +1 more source

Advances in total joint replacement in small animals

Journal of Small Animal Practice, 2012
Total joint replacement is now considered a routine surgical option for small animals with advanced joint disease. This review highlights the current state of the art in total hip, elbow and knee replacement in small animals, as well as the potential for application to other joints such as the intervertebral discs, hock and shoulder.
openaire   +2 more sources

Circumferential Replacement of the Trachea in Experimental Animals

The Annals of Thoracic Surgery, 1968
R R, Shaw, A, Aslami, W R, Webb
openaire   +2 more sources