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Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland [PDF]
ATLA Alternatives To Laboratory AnimalsThis report is a result of an interdisciplinary workshop held at the Collegium Helveticum in Zurich, Switzerland in February 2024, in which ideas for accelerating NAMs (New Approach Methodologies) in Swiss universities were shared and discussed.
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The Replacement of Animal Tests
Alternatives to Laboratory Animals, 2018Progress toward the acceptance and application of validated alternative test methods as replacements for animal tests, is being frustrated by the unsatisfactory procedures involved in approving new test guidelines and deleting existing ...
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Replacing animal experiments: choices, chances and challenges
BioEssays, 2007AbstractReplacing animal procedures with methods such as cells and tissues in vitro, volunteer studies, physicochemical techniques and computer modelling, is driven by legislative, scientific and moral imperatives. Non‐animal approaches are now considered as advanced methods that can overcome many of the limitations of animal experiments.
Langley, Gill +3 more
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Pulmonary in vitro instruments for the replacement of animal experiments
European Journal of Pharmaceutics and Biopharmaceutics, 2021Advanced in vitro systems often combine a mechanical-physical instrument with a biological component e.g. cell culture models. For testing of aerosols, it is of advantage to consider aerosol behavior, particle deposition and lung region specific cell lines.
Daniel, Primavessy +5 more
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Towards Finding Animal Replacement Methods
2017Protecting animal rights and reducing animal suffering in experimentation is a globally recognized goal in science. Yet numbers have been rising, especially in basic research. While most scientists agree that they would prefer to use less invasive methods, studies have shown that current information systems are not equipped to support the search for ...
Dulisch, Nadine, Mathiak, Brigitte
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Animal Studies of Surfactant Replacement Therapy
Developmental Pharmacology and Therapeutics, 2017Before using surfactant preparations in animal experiments or in clinical trials, it is necessary that they fulfil specific in vivo requirements. But conclusive criteria for the effectiveness of a surfactant have not yet been defined. Thus, some standard levels for improvement of lung function, or threshold levels, must be established in standardized ...
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Thyroxine replacement in an animal model of congenital hypothyroidism
Physiology & Behavior, 2007This study examined the effects of thyroxine (T(4)) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T(4) (vehicle) treatment (n=12), T(4) treatment commencing on postnatal day (P-) 7 (n=14), and T(4) treatment commencing on P ...
Reid, R.E. +4 more
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Non-animal Replacements for Acute Toxicity Testing
Alternatives to Laboratory Animals, 2015Current approaches to predicting adverse effects in humans from acute toxic exposure to cosmetic ingredients still heavily necessitate the use of animals under EU legislation, particularly in the context of the REACH system, when cosmetic ingredients are also destined for use in other industries.
Carol, Barker-Treasure +6 more
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1989
People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
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People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
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Diaphragm replacement – an experimental animal study
Langenbecks Archiv für Chirurgie, 1997We performed an open experimental study for evaluation of rapidly absorbable material of bovine serosa for diaphragm replacement. A total of 100 Sprague-Dawley rats were randomly assigned to five groups of equal size. In the control group (n=20) incision of the diaphragm was followed by primary suture.
G. Steinau +3 more
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