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Towards Finding Animal Replacement Methods
2017Protecting animal rights and reducing animal suffering in experimentation is a globally recognized goal in science. Yet numbers have been rising, especially in basic research. While most scientists agree that they would prefer to use less invasive methods, studies have shown that current information systems are not equipped to support the search for ...
Dulisch, Nadine, Mathiak, Brigitte
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Animal Studies of Surfactant Replacement Therapy
Developmental Pharmacology and Therapeutics, 1989Before using surfactant preparations in animal experiments or in clinical trials, it is necessary that they fulfil specific in vivo requirements. But conclusive criteria for the effectiveness of a surfactant have not yet been defined. Thus, some standard levels for improvement of lung function, or threshold levels, must be established in standardized ...
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Thyroxine replacement in an animal model of congenital hypothyroidism
Physiology & Behavior, 2007This study examined the effects of thyroxine (T(4)) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T(4) (vehicle) treatment (n=12), T(4) treatment commencing on postnatal day (P-) 7 (n=14), and T(4) treatment commencing on P ...
Reid, R.E. +4 more
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Non-animal Replacements for Acute Toxicity Testing
Alternatives to Laboratory Animals, 2015Current approaches to predicting adverse effects in humans from acute toxic exposure to cosmetic ingredients still heavily necessitate the use of animals under EU legislation, particularly in the context of the REACH system, when cosmetic ingredients are also destined for use in other industries.
Carol, Barker-Treasure +6 more
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1989
People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
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People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
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Diaphragm replacement – an experimental animal study
Langenbecks Archiv für Chirurgie, 1997We performed an open experimental study for evaluation of rapidly absorbable material of bovine serosa for diaphragm replacement. A total of 100 Sprague-Dawley rats were randomly assigned to five groups of equal size. In the control group (n=20) incision of the diaphragm was followed by primary suture.
G. Steinau +3 more
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HPLC as a replacement for the animal response assays for insulin
Journal of Pharmaceutical and Biomedical Analysis, 1986The work describes the assay of the potency of insulin (drug substance) and its formulations by gradient elution reversed-phase high-performance liquid chromatography (HPLC). The methods are shown to differentiate between insulins of bovine, porcine and human sequence, and to be both reproducible and stability-indicating.
B V, Fisher, D, Smith
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Replacing experiments on laboratory animals
Trends in Biochemical Sciences, 1986There is great scope for overcoming the moral dilemma inherent in experiments using live animals by reducing the numbers of animals required, minimizing any suffering caused, and, in many cases, replacing them altogether through the development, validation and application of alternative methods.
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Technology Feature | Replacing the replacements: Animal model alternatives
Science, 2018Advances in biosensors and microfluidic devices are driving a quiet revolution in biomedical research, which could lead to the reduction or elimination of animal use in many experiments..
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Trends in Animal Use and Replacement in the ‘Three Is’ of Industry
Alternatives to Laboratory Animals, 2012The chemical industry has much to learn from the cosmetics and pharmaceutical industries about the replacement of animal tests
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